The Role of in Sarcoidosis: From Antigen to Treatable Trait?

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Aug 26

PMID 36014067

Authors

Raisa Kraaijvanger

Marcel Veltkamp

Affiliations

Soon will be listed here.

Abstract

(, formerly ) is considered to be a non-pathogenic resident of the human skin, as well as mucosal surfaces. However, it also has been demonstrated that plays a pathogenic role in diseases such as acne vulgaris or implant infections after orthopedic surgery. Besides a role in infectious disease, this bacterium also seems to harbor immunomodulatory effects demonstrated by studies using to enhance anti-tumor activity in various cancers or vaccination response. Sarcoidosis is a systemic inflammatory disorder of unknown causes. Cultures of in biopsy samples of sarcoidosis patients, its presence in BAL fluid, tissue samples as well as antibodies against this bacterium found in serum of patients with sarcoidosis suggest an etiological role in this disease. In this review we address the antigenic as well as immunomodulatory potential of with a focus on sarcoidosis. Furthermore, a potential role for antibiotic treatment in patients with sarcoidosis will be explored.

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References

Kelhala H, Palatsi R, Fyhrquist N, Lehtimaki S, Vayrynen J, Kallioinen M . IL-17/Th17 pathway is activated in acne lesions. PLoS One. 2014; 9(8):e105238. PMC: 4143215. DOI: 10.1371/journal.pone.0105238. View

Kinoshita Y, Ishii H, Eishi Y, Uchida K, Yoshimura M, Iwasaki A . Histological differences between sarcoidosis and lung cancer-related sarcoid reaction. Respir Investig. 2020; 58(5):421-424. DOI: 10.1016/j.resinv.2020.04.003. View

Prezant D, Dhala A, Goldstein A, Janus D, Ortiz F, Aldrich T . The incidence, prevalence, and severity of sarcoidosis in New York City firefighters. Chest. 1999; 116(5):1183-93. DOI: 10.1378/chest.116.5.1183. View

Suchankova M, Paulovicova E, Paulovicova L, Majer I, Tedlova E, Novosadova H . Increased antifungal antibodies in bronchoalveolar lavage fluid and serum in pulmonary sarcoidosis. Scand J Immunol. 2015; 81(4):259-64. DOI: 10.1111/sji.12273. View

Davidsson S, Andren O, Ohlson A, Carlsson J, Andersson S, Giunchi F . FOXP3 regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer. Prostate. 2017; 78(1):40-47. PMC: 5725695. DOI: 10.1002/pros.23442. View

Wahlstrom J, Dengjel J, Persson B, Duyar H, Rammensee H, Stevanovic S . Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis. J Clin Invest. 2007; 117(11):3576-82. PMC: 2045606. DOI: 10.1172/JCI32401. View

Yamane H, Tachibana I, Takeda Y, Saito Y, Tamura Y, He P . Propionibacterium acnes-induced hepatic granuloma formation is impaired in mice lacking tetraspanin CD9. J Pathol. 2005; 206(4):486-92. DOI: 10.1002/path.1793. View

Roszkowski W, Roszkowski K, Ko H, Beuth J, Jeljaszewicz J . Immunomodulation by propionibacteria. Zentralbl Bakteriol. 1990; 274(3):289-98. DOI: 10.1016/s0934-8840(11)80686-9. View

Nagy I, Pivarcsi A, Koreck A, Szell M, Urban E, Kemeny L . Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol. 2005; 124(5):931-8. DOI: 10.1111/j.0022-202X.2005.23705.x. View

10.

Wang Y, Hata T, Tong Y, Kao M, Zouboulis C, Gallo R . The Anti-Inflammatory Activities of Propionibacterium acnes CAMP Factor-Targeted Acne Vaccines. J Invest Dermatol. 2018; 138(11):2355-2364. DOI: 10.1016/j.jid.2018.05.032. View

11.

Dang L, Bettegowda C, Huso D, Kinzler K, Vogelstein B . Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci U S A. 2001; 98(26):15155-60. PMC: 64999. DOI: 10.1073/pnas.251543698. View

12.

Kajdasz D, Lackland D, Mohr L, Judson M . A current assessment of rurally linked exposures as potential risk factors for sarcoidosis. Ann Epidemiol. 2001; 11(2):111-7. DOI: 10.1016/s1047-2797(00)00179-4. View

13.

Kistowska M, Meier B, Proust T, Feldmeyer L, Cozzio A, Kuendig T . Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients. J Invest Dermatol. 2014; 135(1):110-118. DOI: 10.1038/jid.2014.290. View

14.

Miyazaki E, Ando M, Fukami T, Nureki S, Eishi Y, Kumamoto T . Minocycline for the treatment of sarcoidosis: is the mechanism of action immunomodulating or antimicrobial effect?. Clin Rheumatol. 2008; 27(9):1195-7. DOI: 10.1007/s10067-008-0903-3. View

15.

Schupp J, Tchaptchet S, Lutzen N, Engelhard P, Muller-Quernheim J, Freudenberg M . Immune response to Propionibacterium acnes in patients with sarcoidosis--in vivo and in vitro. BMC Pulm Med. 2015; 15:75. PMC: 4513400. DOI: 10.1186/s12890-015-0070-7. View

16.

Hawkins C, Shaginurova G, Shelton D, Herazo-Maya J, Oswald-Richter K, Rotsinger J . Local and Systemic CD4 T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. J Immunol Res. 2017; 2017:3642832. PMC: 5695030. DOI: 10.1155/2017/3642832. View

17.

Furusawa H, Suzuki Y, Miyazaki Y, Inase N, Eishi Y . Th1 and Th17 immune responses to viable Propionibacterium acnes in patients with sarcoidosis. Respir Investig. 2012; 50(3):104-9. DOI: 10.1016/j.resinv.2012.07.001. View

18.

Idorn M, Kollgaard T, Kongsted P, Sengelov L, Straten P . Correlation between frequencies of blood monocytic myeloid-derived suppressor cells, regulatory T cells and negative prognostic markers in patients with castration-resistant metastatic prostate cancer. Cancer Immunol Immunother. 2014; 63(11):1177-87. PMC: 11028426. DOI: 10.1007/s00262-014-1591-2. View

19.

Knapp R, Berkowitz R . Corynebacterium parvum as an immunotherapeutic agent in an ovarian cancer model. Am J Obstet Gynecol. 1977; 128(7):782-6. DOI: 10.1016/0002-9378(77)90721-9. View

20.

Tercelj M, Stopinsek S, Ihan A, Salobir B, Simcic S, Wraber B . In vitro and in vivo reactivity to fungal cell wall agents in sarcoidosis. Clin Exp Immunol. 2011; 166(1):87-93. PMC: 3193923. DOI: 10.1111/j.1365-2249.2011.04456.x. View