Rs8177376, Rs611953, Rs3802814, and Rs8177374 Polymorphisms and Their Association with Cervical Cancer Phenotype and Prognosis

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2022 Aug 26

PMID 36011276

Authors

Justina Bekampyte

Aiste Savukaityte

Agne Bartnykaite

Rasa Ugenskiene

Egle Ziliene

Arturas Inciura

Elona Juozaityte

Affiliations

Soon will be listed here.

Abstract

Cervical cancer is one of the most common cancers in women worldwide, which is typically caused by human papillomavirus (HPV). Usually, the toll-like receptor (TLR) signaling pathways eliminate the virus from the organism, but in some cases, persistent infection may develop. Unfortunately, the mechanism of immune tolerance is still unclear. Therefore, this study aimed to analyze rs8177376, rs611953, rs3802814, and rs8177374 polymorphisms and to identify their impact on cervical cancer phenotype and prognosis. This study included 172 cervical cancer patients. Genotyping was performed using the PCR-RFLP assay. Univariate and multivariate logistic regression and Cox's regression models were applied for statistical analysis. The results revealed that older age at the time of diagnosis was statistically linked with the rs8177376 T allele (OR = 2.901, 95% Cl 1.750-4.808, = 0.000) and the rs611953 G allele (OR = 3.258, 95% Cl 1.917-5.536, = 0.000). Moreover, the T allele of rs8177376 (OR = 0.424, 95% Cl 0.220-0.816, = 0.010) was found to be statistically associated with the lower tumor grade. Thus, polymorphisms might be employed in the future as potential biomarkers for determining the phenotype and prognosis of cervical cancer.

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