Role of Ultrasonography in the Diagnosis of Wilms' Tumour

Overview

Journal Children (Basel)

Specialty Health Services

Date 2022 Aug 26

PMID 36010142

Authors

Radu Ninel Balanescu

Alexandru Emil Baetu

Andreea Alecsandra Moga

Laura Balanescu

Affiliations

Soon will be listed here.

Abstract

Background: Wilms' tumour or nephroblastoma is the most common renal malignancy encountered in the paediatric population. Imaging findings are of great importance to the surgeon, the oncologist and the radiologist in the diagnosis and the staging and surveillance of this tumour.

Material And Methods: This study was carried out as a 10-year retrospective study of patients who were diagnosed with Wilms' tumour.

Results: The study included 12 boys and 11 girls. Ultrasound and computed tomography were performed in all cases. Ultrasonography was found to be superior to the CT examination when approximating the antero-posterior and transverse diameters; the computer-tomographic examination is cited as superior for estimating the invasion of nephroblastomas.

Conclusions: Ultrasound has been shown to be effective in detecting the rupture of the renal capsule, tumour calcifications and invasion of the renal vein, pelvis and ureter. However, ultrasound cannot replace CT in the detection of lymphadenopathy and the invasion of adjacent organs.

References

Dumba M, Jawad N, McHugh K . Neuroblastoma and nephroblastoma: a radiological review. Cancer Imaging. 2015; 15:5. PMC: 4446071. DOI: 10.1186/s40644-015-0040-6. View

Servaes S, Hoffer F, Smith E, Khanna G . Imaging of Wilms tumor: an update. Pediatr Radiol. 2019; 49(11):1441-1452. DOI: 10.1007/s00247-019-04423-3. View

Olukayode A, Richard I, Rachael A, Babajide O, Ireti O, Gbolahan O . Pattern of computed tomography scan findings in children with Wilms' tumor in a tertiary hospital in Lagos, Nigeria. Indian J Med Paediatr Oncol. 2014; 35(1):31-5. PMC: 4080660. DOI: 10.4103/0971-5851.133713. View

Khanna G, Rosen N, Anderson J, Ehrlich P, Dome J, Gow K . Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011; 58(4):551-5. PMC: 3175263. DOI: 10.1002/pbc.23222. View

Daw N, Kauffman W, Bodner S, Pratt C, Hoffer F . Patterns of abdominal relapse and role of sonography in Wilms tumor. Pediatr Hematol Oncol. 2002; 19(2):107-15. DOI: 10.1080/08880010252825696. View

Chu A, Heck J, Ribeiro K, Brennan P, Boffetta P, Buffler P . Wilms' tumour: a systematic review of risk factors and meta-analysis. Paediatr Perinat Epidemiol. 2010; 24(5):449-69. DOI: 10.1111/j.1365-3016.2010.01133.x. View

Xu S, Sun N, Zhang W, Song H, Huang C . Management of Wilms tumor with intravenous thrombus in children: a single center experience. World J Pediatr. 2019; 15(5):476-482. PMC: 6785647. DOI: 10.1007/s12519-019-00272-0. View

Brisse H, Smets A, Kaste S, Owens C . Imaging in unilateral Wilms tumour. Pediatr Radiol. 2007; 38(1):18-29. DOI: 10.1007/s00247-007-0677-9. View

Aldrink J, Heaton T, Dasgupta R, Lautz T, Malek M, Abdessalam S . Update on Wilms tumor. J Pediatr Surg. 2018; 54(3):390-397. PMC: 7542630. DOI: 10.1016/j.jpedsurg.2018.09.005. View

10.

Israels T, Borgstein E, Pidini D, Chagaluka G, de Kraker J, Kamiza S . Management of children with a Wilms tumor in Malawi, sub-Saharan Africa. J Pediatr Hematol Oncol. 2012; 34(8):606-10. DOI: 10.1097/MPH.0b013e3182580921. View

11.

Illade L, Hernandez-Marques C, Cormenzana M, Lassaletta A, Andion Catalan M, Ruano D . [Wilms' tumour: A review of 15 years recent experience]. An Pediatr (Engl Ed). 2017; 88(3):140-149. DOI: 10.1016/j.anpedi.2017.03.019. View

12.

Jedrzejewski G, Wozniak M, Pawelec A, Matera A, Kunach M, Madej T . Ultrasound screening for neoplasms in children up to 6 years old. Medicine (Baltimore). 2016; 95(42):e5124. PMC: 5079325. DOI: 10.1097/MD.0000000000005124. View

13.

Brok J, Lopez-Yurda M, Tinteren H, Treger T, Furtwangler R, Graf N . Relapse of Wilms' tumour and detection methods: a retrospective analysis of the 2001 Renal Tumour Study Group-International Society of Paediatric Oncology Wilms' tumour protocol database. Lancet Oncol. 2018; 19(8):1072-1081. DOI: 10.1016/S1470-2045(18)30293-6. View

14.

Ko E, Ritchey M . Current management of Wilms' tumor in children. J Pediatr Urol. 2008; 5(1):56-65. DOI: 10.1016/j.jpurol.2008.08.007. View

15.

Kosiak M, Stefanowicz J, Adamkiewicz-Drozynska E, Balcerska A, Kurylak A, Demidowicz E . Sonographic Image of Solitary Kidney in Wilms Tumour Survivors. Kidney Blood Press Res. 2018; 43(4):1363-1374. DOI: 10.1159/000492951. View

16.

Fernandez C, Perlman E, Mullen E, Chi Y, Hamilton T, Gow K . Clinical Outcome and Biological Predictors of Relapse After Nephrectomy Only for Very Low-risk Wilms Tumor: A Report From Children's Oncology Group AREN0532. Ann Surg. 2016; 265(4):835-840. PMC: 5145762. DOI: 10.1097/SLA.0000000000001716. View