The Role of Adiponectin in the Resolution of Male-Obesity-Associated Secondary Hypogonadism After Metabolic Surgery and Its Impact on Cardiovascular Risk

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Aug 26

PMID 36009547

Authors

Pilar Cobeta

Roberto Pariente

Alvaro Osorio

Marta Marchan

Marta Cuadrado-Ayuso

David Pestana

Julio Galindo

Jose I Botella-Carretero

Affiliations

Soon will be listed here.

Abstract

Male-obesity-associated secondary hypogonadism (MOSH) is a very prevalent entity that may resolve after marked weight loss. Adiponectin (APN) is an adipokine with anti-inflammatory properties that regulates metabolism. Low-circulating APN is associated with obesity, diabetes, and cardiovascular risk, along with circulating testosterone. We aimed to evaluate APN changes in men with MOSH (low circulating free testosterone (FT) with low or normal gonadotropins) and without it after metabolic surgery. We look for their possible association with cardiovascular risk measured by carotid intima-media thickness (cIMT). We included 60 men (20 submitted to lifestyle modification, 20 to sleeve gastrectomy, and 20 to gastric bypass) evaluated at baseline and 6 months after. The increase in APN at follow-up was reduction in patients with persistent MOSH ( = 10) vs. those without MOSH ( = 30) and MOSH resolution ( = 20), and the former did not achieve a decrease in cIMT. The increase in APN correlated positively with FT (r = 0.320, = 0.013) and inversely with cIMT (r = -0.283, = 0.028). FT inversely correlated with cIMT (r = -0.269, = 0.038). In conclusion, men without MOSH or with MOSH resolution showed a high increase in APN after weight loss with beneficial effects on cIMT. Those without MOSH resolution failed to attain these effects.

Citing Articles

The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men.

Cobeta P, Pariente R, Osorio A, Marchan M, Blazquez L, Pestana D Biomolecules. 2022; 12(12).

PMID: 36551255 PMC: 9775021. DOI: 10.3390/biom12121827.

References

Gardener H, Sjoberg C, Crisby M, Goldberg R, Mendez A, Wright C . Adiponectin and carotid intima-media thickness in the northern Manhattan study. Stroke. 2011; 43(4):1123-5. PMC: 3314722. DOI: 10.1161/STROKEAHA.111.641761. View

Askarpour M, Alizadeh S, Hadi A, Symonds M, Miraghajani M, Sheikhi A . Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis. Horm Metab Res. 2020; 52(4):207-215. DOI: 10.1055/a-1129-6785. View

English K, Mandour O, Steeds R, Diver M, Jones T, Channer K . Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J. 2000; 21(11):890-4. DOI: 10.1053/euhj.1999.1873. View

Rigon F, Ronsoni M, Hohl A, van de Sande-Lee S . Effects of Bariatric Surgery in Male Obesity-Associated Hypogonadism. Obes Surg. 2019; 29(7):2115-2125. DOI: 10.1007/s11695-019-03829-0. View

Hui E, Xu A, Chow W, Lee P, Fong C, Cheung S . Hypoadiponectinemia as an independent predictor for the progression of carotid atherosclerosis: a 5-year prospective study. Metab Syndr Relat Disord. 2014; 12(10):517-22. PMC: 4241893. DOI: 10.1089/met.2014.0024. View

Illan-Gomez F, Gonzalvez-Ortega M, Orea-Soler I, Alcaraz-Tafalla M, Aragon-Alonso A, Pascual-Diaz M . Obesity and inflammation: change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery. Obes Surg. 2012; 22(6):950-5. DOI: 10.1007/s11695-012-0643-y. View

Herder C, Peltonen M, Svensson P, Carstensen M, Jacobson P, Roden M . Adiponectin and bariatric surgery: associations with diabetes and cardiovascular disease in the Swedish Obese Subjects Study. Diabetes Care. 2014; 37(5):1401-9. DOI: 10.2337/dc13-1362. View

Ballantyne G, Gumbs A, Modlin I . Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin. Obes Surg. 2005; 15(5):692-9. DOI: 10.1381/0960892053923789. View

George J, Millar R, Anderson R . Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology. 2010; 91(4):302-7. DOI: 10.1159/000299767. View

10.

Otani M, Kogo M, Furukawa S, Wakisaka S, Maeda T . The adiponectin paralog C1q/TNF-related protein 3 (CTRP3) stimulates testosterone production through the cAMP/PKA signaling pathway. Cytokine. 2012; 58(2):238-44. DOI: 10.1016/j.cyto.2012.01.018. View

11.

Teerds K, de Rooij D, Keijer J . Functional relationship between obesity and male reproduction: from humans to animal models. Hum Reprod Update. 2011; 17(5):667-83. DOI: 10.1093/humupd/dmr017. View

12.

Fernandez C, Chacko E, Pappachan J . Male Obesity-related Secondary Hypogonadism - Pathophysiology, Clinical Implications and Management. Eur Endocrinol. 2019; 15(2):83-90. PMC: 6785957. DOI: 10.17925/EE.2019.15.2.83. View

13.

Rasul S, Ilhan A, Reiter M, Baumgartner-Parzer S, Kautzky-Willer A . Relations of adiponectin to levels of metabolic parameters and sexual hormones in elderly type 2 diabetic patients. Gend Med. 2011; 8(2):93-102. DOI: 10.1016/j.genm.2011.01.004. View

14.

Malin S, Bena J, Abood B, Pothier C, Bhatt D, Nissen S . Attenuated improvements in adiponectin and fat loss characterize type 2 diabetes non-remission status after bariatric surgery. Diabetes Obes Metab. 2014; 16(12):1230-8. PMC: 4227926. DOI: 10.1111/dom.12376. View

15.

Di Vincenzo A, Busetto L, Vettor R, Rossato M . Obesity, Male Reproductive Function and Bariatric Surgery. Front Endocrinol (Lausanne). 2019; 9:769. PMC: 6305362. DOI: 10.3389/fendo.2018.00769. View

16.

Cobeta P, Osorio A, Cuadrado-Ayuso M, Garcia-Moreno F, Pestana D, Galindo J . Sleeve Gastrectomy and Gastric Bypass Decrease the Carotid Intima-Media Thickness in Obese Men: Association with Weight Loss, Cardiovascular Risk Factors, and Circulating Testosterone. Obes Surg. 2020; 30(3):851-859. DOI: 10.1007/s11695-020-04405-7. View

17.

Sjostrom L . Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study. Int J Obes (Lond). 2009; 32 Suppl 7:S93-7. DOI: 10.1038/ijo.2008.244. View

18.

Elsaied M, Masallat D, Abdel-Hamid I . Correlation of Adiponectin With Testosterone in Patients With and Without Type 2 Diabetes and Erectile Dysfunction. Am J Mens Health. 2018; 13(1):1557988318807049. PMC: 6771219. DOI: 10.1177/1557988318807049. View

19.

Molina-Vega M, Asenjo-Plaza M, Garcia-Ruiz M, Varea-Marineto E, Casal-Nievas N, Alvarez-Millan J . Cross-Sectional, Primary Care-Based Study of the Prevalence of Hypoandrogenemia in Nondiabetic Young Men with Obesity. Obesity (Silver Spring). 2019; 27(10):1584-1590. DOI: 10.1002/oby.22579. View

20.

Sjostrom L, Gummesson A, Sjostrom C, Narbro K, Peltonen M, Wedel H . Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009; 10(7):653-62. DOI: 10.1016/S1470-2045(09)70159-7. View