Potential Targets for Noninvasive Brain Stimulation on Depersonalization-Derealization Disorder

Overview

Journal Brain Sci

Publisher MDPI

Date 2022 Aug 26

PMID 36009174

Authors

Sisi Zheng

Nan Song

Sici Wang

Yanzhe Ning

Hong Zhu

Mingkang Song

Yuan Jia

Hongxiao Jia

Affiliations

Soon will be listed here.

Abstract

Introduction: Non-invasive brain stimulation seems to be beneficial for DPD patients. However, the sites used in previous studies were empirical. Exploring new stimulation locations via functional magnetic resonance imaging may improve the efficacy.

Objectives: The objective was to find potential locations for non-invasive brain stimulation on the depersonalization-derealization disorder.

Methods: We explored the potential brain surface regions from three pipelines: pipeline 1: activation likelihood estimation meta-analysis (five studies with 36 foci included); pipeline 2: functional connectivity analysis based on DPD-network (76 subjects included); and pipeline 3: functional connectivity analysis based on DPD regions of interest from the meta-analysis. Potential targets were the 10-20 system coordinates for brain surface regions.

Results: We identified several potential brain surface regions, including the bilateral medial prefrontal cortex, dorsal lateral prefrontal cortex, superior parietal gyrus, superior temporal gyrus, and right ventrolateral prefrontal cortex as potential sites.

Conclusion: Our findings of the potential stimulation targets might help clinicians optimize the application of non-invasive brain stimulation therapy in individuals with DPD.

Citing Articles

Altered Self-Referential-Related Brain Regions in Depersonalization-Derealization Disorder.

Jia Y, Song N, Ning Y, Zhu H, Dong L, Feng S Brain Behav. 2025; 15(2):e70314.

PMID: 39935045 PMC: 11813808. DOI: 10.1002/brb3.70314.

Unraveling the brain dynamics of Depersonalization-Derealization Disorder: a dynamic functional network connectivity analysis.

Zheng S, Zhang F, Shum H, Zhang H, Song N, Song M BMC Psychiatry. 2024; 24(1):685.

PMID: 39402459 PMC: 11475637. DOI: 10.1186/s12888-024-06096-1.

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