Distribution and Morphological Characteristics of Oligodendrocytes in Selected Areas of the Brain of Male and Female Red Kangaroos ()

Overview

Journal Brain Sci

Publisher MDPI

Date 2022 Aug 26

PMID 36009098

Authors

Agata Wawrzyniak

Krzysztof Balawender

Roman Lalak

Maciej Przemyslaw Golan

Konrad Wrobel

Dariusz Boron

Rafal Staszkiewicz

Beniamin Oskar Grabarek

Affiliations

Soon will be listed here.

Abstract

This study was carried out on six adult red kangaroos of both sexes. To determine the location of the oligodendrocytes (OLGs) of the hippocampus (Hip) and corpus callosum (CC), the method of impregnation of the neuroglia with silver salts was applied. The iron distribution in the OLGs was determined by the histochemical method. The Nissl method was used to determine the location of the brain structure and to analyze the number of OLGs. In the Hip, these cells are located one beside another, mainly in blood vessels and neurons; in the neocortex (NC), they are located in layers I-VI; and in the CC, they are arranged in characteristic rows and accompany both nerve fibers and blood vessels. The analysis of the results obtained by the chosen methods in the Hip, NC, and CC in males and females did not show statistically significant differences in the distribution and location of the red kangaroo OLGs. The involvement of these cells is a physiological process that proceeds in a similar manner throughout the life of individuals and actively influences the metabolism of neurons and myelin.

References

West M, Slomianka L, Gundersen H . Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator. Anat Rec. 1991; 231(4):482-97. DOI: 10.1002/ar.1092310411. View

Hulet S, Menzies S, Connor J . Ferritin binding in the developing mouse brain follows a pattern similar to myelination and is unaffected by the jimpy mutation. Dev Neurosci. 2002; 24(2-3):208-13. DOI: 10.1159/000065704. View

Barres B . The mystery and magic of glia: a perspective on their roles in health and disease. Neuron. 2008; 60(3):430-40. DOI: 10.1016/j.neuron.2008.10.013. View

Watakabe A . Comparative molecular neuroanatomy of mammalian neocortex: what can gene expression tell us about areas and layers?. Dev Growth Differ. 2009; 51(3):343-54. DOI: 10.1111/j.1440-169X.2008.01085.x. View

Connor J . Myelin breakdown in Alzheimer's disease: a commentary. Neurobiol Aging. 2003; 25(1):45-7. DOI: 10.1016/j.neurobiolaging.2003.06.004. View

Monteiro R, Conceicao L, Rocha E . Age changes in cerebellar oligodendrocytes: the appearance of nuclear filaments and increase in the volume density of the nucleus and in the number of dark cell forms. Arch Histol Cytol. 1995; 58(4):417-25. DOI: 10.1679/aohc.58.417. View

Wawrzyniak-Gacek A . Distribution of various types of oligodendrocytes and cellular localisation of iron in the frontal cortex of the adult rat. Folia Morphol (Warsz). 2002; 61(2):115-21. View

Tang W, Fan K, Zhao S, Zhang Y, Li Y, Shao S . Correlations between age, biomedical variables, and cognition in patients with schizophrenia. Schizophr Res Cogn. 2020; 22:100182. PMC: 7303996. DOI: 10.1016/j.scog.2020.100182. View

DAmbrosio R, Wenzel J, Schwartzkroin P, McKhann 2nd G, Janigro D . Functional specialization and topographic segregation of hippocampal astrocytes. J Neurosci. 1998; 18(12):4425-38. PMC: 4093786. View

10.

Mortensen H, Pakkenberg B, Dam M, Dietz R, Sonne C, Mikkelsen B . Quantitative relationships in delphinid neocortex. Front Neuroanat. 2014; 8:132. PMC: 4244864. DOI: 10.3389/fnana.2014.00132. View

11.

Bercury K, Macklin W . Dynamics and mechanisms of CNS myelination. Dev Cell. 2015; 32(4):447-58. PMC: 6715306. DOI: 10.1016/j.devcel.2015.01.016. View

12.

Chen L, Lu W, Yang Z, Yang S, Li C, Shi X . Age-related changes of the oligodendrocytes in rat subcortical white matter. Anat Rec (Hoboken). 2011; 294(3):487-93. DOI: 10.1002/ar.21332. View

13.

Erb G, Osterbur D, Levine S . The distribution of iron in the brain: a phylogenetic analysis using iron histochemistry. Brain Res Dev Brain Res. 1996; 93(1-2):120-8. DOI: 10.1016/0165-3806(96)00020-x. View

14.

Levine S, Macklin W . Iron-enriched oligodendrocytes: a reexamination of their spatial distribution. J Neurosci Res. 1990; 26(4):508-12. DOI: 10.1002/jnr.490260415. View

15.

Pakkenberg B, Gundersen H . Neocortical neuron number in humans: effect of sex and age. J Comp Neurol. 1997; 384(2):312-20. View

16.

Niewiadomska G, Baksalerska-Pazera M, Riedel G . The septo-hippocampal system, learning and recovery of function. Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33(5):791-805. DOI: 10.1016/j.pnpbp.2009.03.039. View

17.

Del Zoppo G, Milner R, Mabuchi T, Hung S, Wang X, Koziol J . Vascular matrix adhesion and the blood-brain barrier. Biochem Soc Trans. 2006; 34(Pt 6):1261-6. DOI: 10.1042/BST0341261. View

18.

Mori S, Leblond C . Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats. J Comp Neurol. 1970; 139(1):1-28. DOI: 10.1002/cne.901390102. View

19.

Cerghet M, Skoff R, Bessert D, Zhang Z, Mullins C, Ghandour M . Proliferation and death of oligodendrocytes and myelin proteins are differentially regulated in male and female rodents. J Neurosci. 2006; 26(5):1439-47. PMC: 6675481. DOI: 10.1523/JNEUROSCI.2219-05.2006. View

20.

Simpson I, Ponnuru P, Klinger M, Myers R, Devraj K, Coe C . A novel model for brain iron uptake: introducing the concept of regulation. J Cereb Blood Flow Metab. 2014; 35(1):48-57. PMC: 4294394. DOI: 10.1038/jcbfm.2014.168. View