HPV and Vaginal Microecological Disorders in Infertile Women: a Cross-sectional Study in the Chinese Population

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2022 Aug 25

PMID 36008847

Authors

Li Wang

Lin He

Junyu Chen

Shuyao Wei

Hongzhou Xu

Mengjun Luo

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of this study was to evaluate the distributions of vaginal microbiome dysbiosis and human papillomavirus (HPV) subtypes in infertile women and explore the correlations of HPV infection and vaginal microbiome dysbiosis with infertility.

Methods: In total, 1464 women aged 18-50 years were included in this study; 649 participants were included in the infertility group, and 815 participants were included in the normal group. The participants were tested for HPV, and their vaginal microecology was examined. The χ test and Spearman regression were used for statistical analysis, and binary logistic regression was performed to identify the risk factors for infertility.

Results: The patients in the infertility group were younger than those in the normal group, and the proportions of bacterial vaginosis and vaginal imbalance in the infertility group were significantly higher than those in the normal group. The incidence proportions of high-risk HPV types in the infertility group were significantly higher than those in the normal group, and the proportions of high-risk subtytes HPV16, HPV39, HV52, HPV56, and HPV68 were significantly higher in the infertility group than in the normal group. However, there were no significant differences in the incidences of low-risk HPV types. The incidence proportions of vaginal flora imbalance and HPV infection in the infertility group were significantly higher than those in the normal group. HPV16, HPV33, HPV51, HPV52and HPV58 infections were independent risk factors for infertility.

Conclusions: Vaginal microecological imbalance and HPV infection are directly related to infertility, and precautions should be taken.

Citing Articles

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HPV infection and vaginal microecological disorders in women with intrauterine adhesion: cross-sectional study in a Chinese population.

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References

Dai Q, Hu L, Jiang Y, Shi H, Liu J, Zhou W . An epidemiological survey of bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis in the Tibetan area of Sichuan Province, China. Eur J Obstet Gynecol Reprod Biol. 2010; 150(2):207-9. DOI: 10.1016/j.ejogrb.2010.02.027. View

Kovachev S . Defence factors of vaginal lactobacilli. Crit Rev Microbiol. 2017; 44(1):31-39. DOI: 10.1080/1040841X.2017.1306688. View

Tsevat D, Wiesenfeld H, Parks C, Peipert J . Sexually transmitted diseases and infertility. Am J Obstet Gynecol. 2016; 216(1):1-9. PMC: 5193130. DOI: 10.1016/j.ajog.2016.08.008. View

Vander Borght M, Wyns C . Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018; 62:2-10. DOI: 10.1016/j.clinbiochem.2018.03.012. View

Goulart A, Farnezi H, Franca J, Santos A, Ramos M, Penna M . HIV, HPV and Chlamydia trachomatis: impacts on male fertility. JBRA Assist Reprod. 2020; 24(4):492-497. PMC: 7558888. DOI: 10.5935/1518-0557.20200020. View

Matovina M, Husnjak K, Milutin N, Ciglar S, Grce M . Possible role of bacterial and viral infections in miscarriages. Fertil Steril. 2004; 81(3):662-9. DOI: 10.1016/j.fertnstert.2003.08.020. View

Jaworek H, Koudelakova V, Oborna I, Zborilova B, Brezinova J, Ruzickova D . Prevalence and genotype distribution of human papillomavirus in Czech non-vaccinated heterosexual couples. Virol J. 2021; 18(1):80. PMC: 8051085. DOI: 10.1186/s12985-021-01551-x. View

Ravel J, Gajer P, Abdo Z, Schneider G, Koenig S, McCulle S . Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 2010; 108 Suppl 1:4680-7. PMC: 3063603. DOI: 10.1073/pnas.1002611107. View

Oakeshott P, Aghaizu A, Reid F, Howell-Jones R, Hay P, Sadiq S . Frequency and risk factors for prevalent, incident, and persistent genital carcinogenic human papillomavirus infection in sexually active women: community based cohort study. BMJ. 2012; 344:e4168. PMC: 3382227. DOI: 10.1136/bmj.e4168. View

10.

Yu F, Tang Y, Hu Z, Lin X . Analysis of the Vaginal Microecological Status and Genital Tract Infection Characteristics of 751 Pregnant Women. Med Sci Monit. 2018; 24:5338-5345. PMC: 6085980. DOI: 10.12659/MSM.909051. View

11.

Van Schalkwyk J, Yudin M . Vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis. J Obstet Gynaecol Can. 2015; 37(3):266-274. DOI: 10.1016/S1701-2163(15)30316-9. View

12.

Ravel J, Moreno I, Simon C . Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. Am J Obstet Gynecol. 2020; 224(3):251-257. DOI: 10.1016/j.ajog.2020.10.019. View

13.

Tamrakar S, Bastakoti R . Determinants of Infertility in Couples. J Nepal Health Res Counc. 2019; 17(1):85-89. DOI: 10.33314/jnhrc.1827. View

14.

Paul P, Hammer A, Rositch A, Burke A, Viscidi R, Silver M . Rates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior. J Infect Dis. 2020; 223(8):1423-1432. PMC: 8064050. DOI: 10.1093/infdis/jiaa557. View

15.

Lisyana T, Ponomareva I, Katzalap O, Timofeieva A . [The micro-ecology of genital tracts in women with infertility of chlamydia nature.]. Klin Lab Diagn. 2019; 61(12):853-857. DOI: 10.18821/0869-2084-2016-61-12-853-857. View

16.

Mitra A, MacIntyre D, Marchesi J, Lee Y, Bennett P, Kyrgiou M . The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?. Microbiome. 2016; 4(1):58. PMC: 5088670. DOI: 10.1186/s40168-016-0203-0. View

17.

Gomez L, Ma Y, Ho C, McGrath C, Nelson D, Parry S . Placental infection with human papillomavirus is associated with spontaneous preterm delivery. Hum Reprod. 2008; 23(3):709-15. DOI: 10.1093/humrep/dem404. View

18.

Zaki M, Raafat D, El Emshaty W, Azab M, Goda H . Correlation of Trichomonas vaginalis to bacterial vaginosis: a laboratory-based study. J Infect Dev Ctries. 2010; 4(3):156-63. DOI: 10.3855/jidc.434. View

19.

Ambuhl L, Baandrup U, Dybkaer K, Blaakaer J, Uldbjerg N, Sorensen S . Human Papillomavirus Infection as a Possible Cause of Spontaneous Abortion and Spontaneous Preterm Delivery. Infect Dis Obstet Gynecol. 2016; 2016:3086036. PMC: 4826700. DOI: 10.1155/2016/3086036. View

20.

Souho T, Benlemlih M, Bennani B . Human papillomavirus infection and fertility alteration: a systematic review. PLoS One. 2015; 10(5):e0126936. PMC: 4436317. DOI: 10.1371/journal.pone.0126936. View