The MicroRNA-10b-Bim Axis Promotes Cancer Progression Through Activating Autophagy in Oral Squamous Cell Carcinoma

Overview

Journal Cell Death Discov

Date 2022 Aug 25

PMID 36008375

Authors

Shaoming Li

Ling Gao

Jiacheng Liu

Chao Guo

Jingjing Zheng

Keqian Zhi

Wenhao Ren

Affiliations

Soon will be listed here.

Abstract

Autophagy is related to many cellular mechanisms and dysregulation of autophagy involves the pathological process in cancer. miR-10b activates autophagy, which promotes invasion and migration of OSCC. Its functional role in the mechanism of OSCC to autophagy remains to be unclear. Overexpression of miR-10b was followed by enhanced OSCC invasion and migration and activated autophagic protein, such as LC3II/ATG5. MiR-10b attracted Bim directly according to the Bio-informatics analyses and double luciferases reporter assays. Functional experiments further revealed that miR-10b could promote invasion and migration in vitro. In addition, miR-10b induced autophagy via inhibiting Bim in invasion and migration of OSCC. Notably, animal experiments confirmed that miR-10b-Bim promoted proliferation and autophagy in OSCC. In addition, this study provides a theoretical support for regulating the mechanism of OSCC by inducing autophagy with miR-10b-Bim as a target.

Citing Articles

Comparison of DPPIV Levels in Serum and Tumour of OSCC Patients and Its Correlation with Active Matrix Metalloproteinases 2 and 9.

Taheri A, Lashkarbolouki T, Karimi A, Sirati-Sabet M, Karima S, Goudarzi A Asian Pac J Cancer Prev. 2023; 24(4):1343-1349.

PMID: 37116157 PMC: 10352756. DOI: 10.31557/APJCP.2023.24.4.1343.

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