Prognostic Value of Highly-sensitive Troponin in Preeclampsia

Overview

Journal Tunis Med

Specialty General Medicine

Date 2022 Aug 25

PMID 36005920

Authors

Abderrahmen Ben Gharbia

Bassem Rekik

Sofiene Ben Marzouk

Hayen Maghrebi

Affiliations

Soon will be listed here.

Abstract

Introduction: Pre-eclampsia is a pregnancy complication leading to significant morbidity and mortality. High-sensitivity troponin (hs-cTnI ) is one of the most sensitive cardiac biomarkers, but its variation in preeclampsia remains poorly studied.

Aim: To assess the prognostic value of hyper-sensitive troponin in preeclampsia.

Methods: It was a prospective study including patients with preeclampsia. The exclusion criteria included conditions that may cause an elevation of hs-cTnI. Preoperative laboratory assessment included the determination of the level of hs-cTnI. The discriminative value of the preoperative hs-cTnI allowing to predict the onset of complications was evaluated by the ROC curve. Group A included patients whose rate was above the calculated cutoff, and group B included the others.

Results: Seventy seven patients were included. Complications occurred in 22% of cases. The preoperative hs-cTnI cutoff of 6.3 ng/l predicted the onset of complications (sensitivity 70.6% / specificity 86.6% / p < 0.0001). There was a higher rate of severe pre-eclampsia and complications, a higher systolic and mean arterial blood pressure values in group A with significant differences. Both groups were comparable demographically, obstetrically, clinically and biologically.

Conclusion: According to the results of our study, increased values of preoperative hs-cTnI may predict the onset of complications in pregnancies complicated by preeclampsia.

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