Th2A Cells: The Pathogenic Players in Allergic Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Aug 25

PMID 36003397

Authors

Ziyu Huang

Ming Chu

Xi Chen

Ziyuan Wang

Lin Jiang

Yinchao Ma

Yuedan Wang

Affiliations

Soon will be listed here.

Abstract

Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3 CD4 HPGDS CRTH2 CD161 ST2 CD49d CD27 play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases.

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References

Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N . Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nat Struct Biol. 2003; 10(4):291-6. DOI: 10.1038/nsb907. View

Fergusson J, Fleming V, Klenerman P . CD161-expressing human T cells. Front Immunol. 2012; 2:36. PMC: 3342360. DOI: 10.3389/fimmu.2011.00036. View

Xue L, Barrow A, Pettipher R . Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells. Clin Exp Immunol. 2009; 156(1):126-33. PMC: 2673750. DOI: 10.1111/j.1365-2249.2008.03871.x. View

Zeidan Y, Hannun Y . The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med. 2010; 10(5):454-66. DOI: 10.2174/156652410791608225. View

Bischoff S . Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol. 2007; 7(2):93-104. DOI: 10.1038/nri2018. View

Rutkowski K, Sowa P, Rutkowska-Talipska J, Sulkowski S, Rutkowski R . Allergic diseases: the price of civilisational progress. Postepy Dermatol Alergol. 2014; 31(2):77-83. PMC: 4112251. DOI: 10.5114/pdia.2014.40936. View

Hazenberg M, Spits H . Human innate lymphoid cells. Blood. 2014; 124(5):700-9. DOI: 10.1182/blood-2013-11-427781. View

Morgan D, Ruiter B, Smith N, Tu A, Monian B, Stone B . Clonally expanded, GPR15-expressing pathogenic effector T2 cells are associated with eosinophilic esophagitis. Sci Immunol. 2021; 6(62). PMC: 8686696. DOI: 10.1126/sciimmunol.abi5586. View

Yang D, Chen Q, Su S, Zhang P, Kurosaka K, Caspi R . Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med. 2008; 205(1):79-90. PMC: 2234357. DOI: 10.1084/jem.20062027. View

10.

Vandamme C, Rytkonen-Nissinen M, Lonnberg T, Randell J, Harvima R, Kinnunen T . Single-cell characterization of dog allergen-specific T cells reveals T2 heterogeneity in allergic individuals. J Allergy Clin Immunol. 2021; 149(5):1732-1743.e15. DOI: 10.1016/j.jaci.2021.11.018. View

11.

Chiang D, Chen X, Jones S, Wood R, Sicherer S, Burks A . Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector T2 subsets. J Allergy Clin Immunol. 2018; 141(6):2107-2120. PMC: 5994177. DOI: 10.1016/j.jaci.2017.11.060. View

12.

Iinuma T, Okamoto Y, Yamamoto H, Inamine-Sasaki A, Ohki Y, Sakurai T . Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2015; 114(4):289-98. DOI: 10.1016/j.anai.2015.01.013. View

13.

Bai A, Guo Y . Acid sphingomyelinase mediates human CD4 T-cell signaling: potential roles in T-cell responses and diseases. Cell Death Dis. 2017; 8(7):e2963. PMC: 5550889. DOI: 10.1038/cddis.2017.360. View

14.

Rittchen S, Heinemann A . Therapeutic Potential of Hematopoietic Prostaglandin D Synthase in Allergic Inflammation. Cells. 2019; 8(6). PMC: 6628301. DOI: 10.3390/cells8060619. View

15.

Kostenis E, Ulven T . Emerging roles of DP and CRTH2 in allergic inflammation. Trends Mol Med. 2006; 12(4):148-58. DOI: 10.1016/j.molmed.2006.02.005. View

16.

Yii A, Tay T, Choo X, Koh M, Tee A, Wang D . Precision medicine in united airways disease: A "treatable traits" approach. Allergy. 2018; 73(10):1964-1978. DOI: 10.1111/all.13496. View

17.

Bonvalet M, Moussu H, Wambre E, Ricarte C, Horiot S, Rimaniol A . Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy. Clin Exp Allergy. 2012; 42(12):1745-55. DOI: 10.1111/cea.12015. View

18.

Grassme H, Jekle A, Riehle A, Schwarz H, Berger J, Sandhoff K . CD95 signaling via ceramide-rich membrane rafts. J Biol Chem. 2001; 276(23):20589-96. DOI: 10.1074/jbc.M101207200. View

19.

Tavares L, Negreiros-Lima G, Lima K, E Silva P, Pinho V, Teixeira M . Blame the signaling: Role of cAMP for the resolution of inflammation. Pharmacol Res. 2020; 159:105030. DOI: 10.1016/j.phrs.2020.105030. View

20.

Gaud G, Lesourne R, Love P . Regulatory mechanisms in T cell receptor signalling. Nat Rev Immunol. 2018; 18(8):485-497. DOI: 10.1038/s41577-018-0020-8. View