COVID-19 Infection and Renal Injury: Where is the Place for Acute Interstitial Nephritis Disease?

Overview

Journal Clin Kidney J

Publisher Oxford University Press

Specialty Nephrology

Date 2022 Aug 24

PMID 35999963

Authors

Juan Leon-Roman

Irene Agraz

Ander Vergara

Natalia Ramos

Nestor Toapanta

Clara Garcia-Carro

Alejandra Gabaldon

Roxana Bury

Sheila Bermejo

Oriol Bestard

Maria Jose Soler

Affiliations

Soon will be listed here.

Abstract

Novel coronavirus disease infection (coronavirus disease 2019, COVID-19) was declared a global pandemic in March 2020 and since then has become a major public health problem. The prevalence of COVID-19 infection and acute kidney injury (AKI) is variable depending on several factors such as race/ethnicity and severity of illness. The pathophysiology of renal involvement in COVID-19 infection is not entirely clear, but it could be in part explained by the viral tropism in the kidney parenchyma. AKI in COVID-19 infection can be either by direct invasion of the virus or as a consequence of immunologic response. Diverse studies have focused on the effect of COVID-19 on glomerulonephritis (GN) patients or the 'novo' GN; however, the effect of COVID-19 in acute tubulointerstitial nephritis (ATIN) has been scarcely studied. In this article, we present five cases with different spectrums of COVID-19 infection and ATIN that may suggest that recent diagnosis of ATIN is accompanied by a worse clinical prognosis in comparison with long-term diagnosed ATIN.

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