Diagnostic MALDI-TOF MS Can Differentiate Between High and Low Toxic Bacteraemia Isolates As a Predictor of Patient Outcome

Overview

Journal Microbiology (Reading)

Specialty Microbiology

Date 2022 Aug 23

PMID 35997594

Authors

Tarcisio Brignoli

Mario Recker

Winnie W Y Lee

Tim Dong

Ranjeet Bhamber

Mahableshwar Albur

Philip Williams

Andrew W Dowsey

Ruth C Massey

Affiliations

Soon will be listed here.

Abstract

bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.

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