The DYF-5 RCK and CDKL-1 CDKL5 Kinases Contribute Differentially to Shape Distinct Sensory Neuron Cilia Morphologies in

Overview

Journal MicroPubl Biol

Specialty Biology

Date 2022 Aug 23

PMID 35996689

Authors

Ashish Kumar Maurya

Piali Sengupta

Affiliations

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Abstract

The conserved CCRK, RCK, and CDKL5 kinases regulate cilia length in diverse organisms. In , DYF-18 CCRK regulates DYF-5 RCK to shape both simple and complex cilia morphologies. The CDKL5 ortholog CDKL-1 has also been suggested to act downstream of DYF-18 but independently of DYF-5 to regulate lengths of simple rod-like cilia. Here we show that CDKL-1 is largely dispensable for regulation of complex cilia structures. Using genetic epistasis experiments, we confirm that CDKL-1 and DYF-5 act independently to control cilia architecture. Our results indicate that multiple kinases act via distinct pathways to regulate unique cilia ultrastructures.

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