Prognostic Significance of Copy Number Variation in B-cell Acute Lymphoblastic Leukemia

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Aug 22

PMID 35992882

Authors

Yang Song

Qiuyun Fang

Yingchang Mi

Affiliations

Soon will be listed here.

Abstract

Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personalized management of this population. The discovery of the molecular mechanism of gene deletion and the development of targeted drugs will further enhance the clinical prognosis of B-ALL.

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