Clinicopathologic Study of Mantle Cell Lymphoma with Epstein-barr Virus Infection: A Case Series and Literature Review

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Aug 22

PMID 35992854

Authors

Xiaoju Li

Fanlin Zhou

Shijie Li

Yangyang Wang

Jianing Fan

Xiao Liang

Yan Peng

Yudi Jin

Weiyang Jiang

Fang Liu

Yixing Zhou

Shuke Liu

Tao Wang

Yi Peng

Jianbo Xiong

Jia Liu

Jing Zhang

Changqing He

Hui Zhang

Yu Li

Affiliations

Soon will be listed here.

Abstract

Background: Mantle cell lymphoma (MCL) with Epstein-Barr virus (EBV) infection is rarely reported. The objective of this study was to analyze the prevalence and clinicopathological features of MCL with EBV infection in the largest series thus far.

Methods: After screening 138 cases of MCL, we identified eight cases of MCL with EBV infection.

Results: Most of them (7/8) had non-neoplastic bystander cells with positivity for EBV and no expression of latent membrane protein 1 (LMP1) and EBV nuclear antigen 2 (EBNA2). The cases of MCL with EBER positivity did not have abnormal immune function or other lymphomas. Moreover, their histopathological morphology was indicative of classical MCL. Cases of MCL with EBER positivity exhibited statistically significant differences in lactate dehydrogenase, anemia status, and MCL international prognostic index grouping (P=0.008, P=0.02, P=0.001, and P=0.011, respectively). The differences between the two groups in age, sex ratio, clinical manifestations, and immunohistochemical phenotypes were not statistically significant.

Conclusions: The incidence of MCL with EBV infection was low (5.8%). Clinicopathologically, cases of MCL with EBER positivity were similar to their EBV-negative counterparts. Our findings revealed that most cells infected by EBV in MCL are background cells rather than tumor cells. This is inconsistent with data from previous studies, indicating that tumor cells in MCL may not be prone to EBV infection.

Citing Articles

EBV-Positive Pleomorphic Variant Transformation of CD5-Negative Mantle Cell Lymphoma: A Rare Case Report and Literature Review.

Song A, Li J, Cockey S, Shao R, Zhang H Case Rep Hematol. 2024; 2024:3267739.

PMID: 38938449 PMC: 11208810. DOI: 10.1155/2024/3267739.

References

Nassif S, Ozdemirli M . EBV-positive low-grade marginal zone lymphoma in the breast with massive amyloid deposition arising in a heart transplant patient: A report of an unusual case. Pediatr Transplant. 2013; 17(6):E141-5. DOI: 10.1111/petr.12111. View

Orlandi E, Paulli M, Viglio A, Pagnucco G, Riboni R, Baldanti F . Epstein-Barr virus-positive aggressive lymphoma as a consequence of immunosuppression after multiple salvage treatments for follicular lymphoma. Br J Haematol. 2001; 112(2):373-6. DOI: 10.1046/j.1365-2141.2001.02579.x. View

Koreishi A, Saenz A, Arcila M, Hedvat C, Fleming S, Teruya-Feldstein J . Synchronous follicular lymphoma, kaposi sarcoma, and castleman's disease in a HIV-negative patient with EBV and HHV-8 coinfection. Int J Surg Pathol. 2009; 19(5):685-91. DOI: 10.1177/1066896909341803. View

Hummel M, Anagnostopoulos I, Korbjuhn P, STEIN H . Epstein-Barr virus in B-cell non-Hodgkin's lymphomas: unexpected infection patterns and different infection incidence in low- and high-grade types. J Pathol. 1995; 175(3):263-71. DOI: 10.1002/path.1711750303. View

Murray C, Quinn F, Illyes G, Walker J, Castriciano G, OSullivan P . Composite Blastoid Variant of Mantle Cell Lymphoma and Classical Hodgkin Lymphoma. Int J Surg Pathol. 2016; 25(3):281-286. DOI: 10.1177/1066896916672556. View

Terasawa T, Ohashi H, Utsumi M, Tsushita K, Kinoshita T, Nakamura S . Case of Epstein-Barr virus-associated transformation of mantle cell lymphoma. Am J Hematol. 2003; 73(3):194-9. DOI: 10.1002/ajh.10343. View

Mori T, Okamoto S, Kuramochi S, Ikeda Y . An adult patient with hypersensitivity to mosquito bites developing mantle cell lymphoma. Int J Hematol. 2000; 71(3):259-62. View

Gualco G, Weiss L, Harrington Jr W, Bacchi C . BCL6, MUM1, and CD10 expression in mantle cell lymphoma. Appl Immunohistochem Mol Morphol. 2009; 18(2):103-8. PMC: 2828511. DOI: 10.1097/PAI.0b013e3181bb9edf. View

Camacho Castaneda F, Dotor A, Manso R, Martin P, Prieto Pareja E, Palomo Esteban T . Epstein-Barr virus-associated large B-cell lymphoma transformation in marginal zone B-cell lymphoma: a series of four cases. Histopathology. 2020; 77(1):112-122. DOI: 10.1111/his.14101. View

10.

Ohashi A, Kato S, Okamoto A, Inaguma Y, Satou A, Tsuzuki T . Reappraisal of Epstein-Barr virus (EBV) in diffuse large B-cell lymphoma (DLBCL): comparative analysis between EBV-positive and EBV-negative DLBCL with EBV-positive bystander cells. Histopathology. 2017; 71(1):89-97. DOI: 10.1111/his.13197. View

11.

Xu J, Wang L, Li J, Saksena A, Wang S, Shen J . SOX11-negative Mantle Cell Lymphoma: Clinicopathologic and Prognostic Features of 75 Patients. Am J Surg Pathol. 2019; 43(5):710-716. DOI: 10.1097/PAS.0000000000001233. View

12.

Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J . CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients. Am J Surg Pathol. 2019; 43(8):1052-1060. DOI: 10.1097/PAS.0000000000001278. View

13.

Kanai R, Miyagawa-Hayashino A, Shishido-Hara Y, Nakamura N, Omatsu I, Morinaga Y . Mantle cell lymphoma with EBV-positive Hodgkin and Reed-Sternberg-like cells in a patient after autologous PBSCT: Phenotypically distinct but genetically related tumors. Pathol Int. 2020; 71(1):96-101. DOI: 10.1111/pin.13038. View

14.

Liu L, Liu Q, Feng S . Management of Epstein-Barr virus-related post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation. Ther Adv Hematol. 2020; 11:2040620720910964. PMC: 7236397. DOI: 10.1177/2040620720910964. View

15.

Mackrides N, Campuzano-Zuluaga G, Maque-Acosta Y, Moul A, Hijazi N, Ikpatt F . Epstein-Barr virus-positive follicular lymphoma. Mod Pathol. 2016; 30(4):519-529. DOI: 10.1038/modpathol.2016.214. View

16.

Hummel M, Anagnostopoulos I, DALLENBACH F, Korbjuhn P, Dimmler C, STEIN H . EBV infection patterns in Hodgkin's disease and normal lymphoid tissue: expression and cellular localization of EBV gene products. Br J Haematol. 1992; 82(4):689-94. DOI: 10.1111/j.1365-2141.1992.tb06945.x. View

17.

Hatton O, Harris-Arnold A, Schaffert S, Krams S, Martinez O . The interplay between Epstein-Barr virus and B lymphocytes: implications for infection, immunity, and disease. Immunol Res. 2014; 58(2-3):268-76. PMC: 4199828. DOI: 10.1007/s12026-014-8496-1. View

18.

Hoster E, Rosenwald A, Berger F, Bernd H, Hartmann S, Loddenkemper C . Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern in Mantle-Cell Lymphoma: Results From Randomized Trials of the European Mantle Cell Lymphoma Network. J Clin Oncol. 2016; 34(12):1386-94. DOI: 10.1200/JCO.2015.63.8387. View

19.

Pizzi M, Agostinelli C, Righi S, Gazzola A, Mannu C, Galuppini F . Aberrant expression of CD10 and BCL6 in mantle cell lymphoma. Histopathology. 2017; 71(5):769-777. DOI: 10.1111/his.13286. View

20.

Castillo J, Beltran B, Miranda R, Young K, Chavez J, Sotomayor E . EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2018 update on diagnosis, risk-stratification and management. Am J Hematol. 2018; 93(7):953-962. DOI: 10.1002/ajh.25112. View