Non-coding RNAs in Necroptosis, Pyroptosis, and Ferroptosis in Cardiovascular Diseases

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2022 Aug 22

PMID 35990979

Authors

Yuxi Cai

Yiwen Zhou

Zhangwang Li

Panpan Xia

Xinxi ChenFu

Ao Shi

Jing Zhang

Peng Yu

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence has proved that non-coding RNAs (ncRNAs) play a critical role in the genetic programming and gene regulation of cardiovascular diseases (CVDs). Cardiovascular disease morbidity and mortality are rising and have become a primary public health issue that requires immediate resolution through effective intervention. Numerous studies have revealed that new types of cell death, such as pyroptosis, necroptosis, and ferroptosis, play critical cellular roles in CVD progression. It is worth noting that ncRNAs are critical novel regulators of cardiovascular risk factors and cell functions by mediating pyroptosis, necroptosis, and ferroptosis. Thus, ncRNAs can be regarded as promising therapeutic targets for treating and diagnosing cardiovascular diseases. Recently, there has been a surge of interest in the mediation of ncRNAs on three types of cell death in regulating tissue homeostasis and pathophysiological conditions in CVDs. Although our understanding of ncRNAs remains in its infancy, the studies reviewed here may provide important new insights into how ncRNAs interact with CVDs. This review summarizes what is known about the functions of ncRNAs in modulating cell death-associated CVDs and their role in CVDs, as well as their current limitations and future prospects.

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References

Liu J, van Mil A, Vrijsen K, Zhao J, Gao L, Metz C . MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1. J Cell Mol Med. 2010; 15(7):1474-82. PMC: 3823192. DOI: 10.1111/j.1582-4934.2010.01104.x. View

Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J . Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. Cell Death Dis. 2020; 11(7):574. PMC: 7382480. DOI: 10.1038/s41419-020-02777-3. View

Wu X, Li Y, Zhang S, Zhou X . Ferroptosis as a novel therapeutic target for cardiovascular disease. Theranostics. 2021; 11(7):3052-3059. PMC: 7847684. DOI: 10.7150/thno.54113. View

Wang Y, Qiu Z, Yuan J, Li C, Zhao R, Liu W . Hypoxia-reoxygenation induces macrophage polarization and causes the release of exosomal miR-29a to mediate cardiomyocyte pyroptosis. In Vitro Cell Dev Biol Anim. 2021; 57(1):30-41. DOI: 10.1007/s11626-020-00524-8. View

Zhaolin Z, Guohua L, Shiyuan W, Zuo W . Role of pyroptosis in cardiovascular disease. Cell Prolif. 2018; 52(2):e12563. PMC: 6496801. DOI: 10.1111/cpr.12563. View

Zhu Y, Wang R, Chen W, Cao Y, Li L, Chen X . miR-133a-3p attenuates cardiomyocyte hypertrophy through inhibiting pyroptosis activation by targeting IKKε. Acta Histochem. 2020; 123(1):151653. DOI: 10.1016/j.acthis.2020.151653. View

Chevion M, Jiang Y, Berenshtein E, Uretzky G, Kitrossky N . Copper and iron are mobilized following myocardial ischemia: possible predictive criteria for tissue injury. Proc Natl Acad Sci U S A. 1993; 90(3):1102-6. PMC: 45819. DOI: 10.1073/pnas.90.3.1102. View

Ding S, Liu D, Wang L, Wang G, Zhu Y . Inhibiting MicroRNA-29a Protects Myocardial Ischemia-Reperfusion Injury by Targeting SIRT1 and Suppressing Oxidative Stress and NLRP3-Mediated Pyroptosis Pathway. J Pharmacol Exp Ther. 2019; 372(1):128-135. DOI: 10.1124/jpet.119.256982. View

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K . Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018; 172(3):409-422.e21. DOI: 10.1016/j.cell.2017.11.048. View

10.

Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M . RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. Cardiovasc Res. 2014; 103(2):206-16. DOI: 10.1093/cvr/cvu146. View

11.

Shi P, Zhao X, Shi K, Ding X, Tao H . MiR-21-3p triggers cardiac fibroblasts pyroptosis in diabetic cardiac fibrosis via inhibiting androgen receptor. Exp Cell Res. 2021; 399(2):112464. DOI: 10.1016/j.yexcr.2020.112464. View

12.

Oerlemans M, Liu J, Arslan F, den Ouden K, van Middelaar B, Doevendans P . Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo. Basic Res Cardiol. 2012; 107(4):270. DOI: 10.1007/s00395-012-0270-8. View

13.

Eltzschig H, Eckle T . Ischemia and reperfusion--from mechanism to translation. Nat Med. 2011; 17(11):1391-401. PMC: 3886192. DOI: 10.1038/nm.2507. View

14.

Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z . Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. Cell Death Dis. 2018; 9(2):171. PMC: 5833729. DOI: 10.1038/s41419-017-0257-3. View

15.

Xu C, Jia Z, Cao X, Wang S, Wang J, An L . Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383. Cell Cycle. 2022; 21(10):1003-1019. PMC: 9037457. DOI: 10.1080/15384101.2022.2040122. View

16.

Wilhelm M, Schlegl J, Hahne H, Gholami A, Lieberenz M, Savitski M . Mass-spectrometry-based draft of the human proteome. Nature. 2014; 509(7502):582-7. DOI: 10.1038/nature13319. View

17.

Wang K, Liu F, Liu C, An T, Zhang J, Zhou L . The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873. Cell Death Differ. 2016; 23(8):1394-405. PMC: 4947670. DOI: 10.1038/cdd.2016.28. View

18.

Shah S, Khan M, Jo M, Jo M, Ul Amin F, Kim M . Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain. CNS Neurosci Ther. 2016; 23(1):33-44. PMC: 6492734. DOI: 10.1111/cns.12588. View

19.

Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P . Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014; 15(2):135-47. DOI: 10.1038/nrm3737. View

20.

Lu J, Xu F, Lu H . LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53. Life Sci. 2020; 260:118305. DOI: 10.1016/j.lfs.2020.118305. View