CD4 T Cell Metabolism, Gut Microbiota, and Autoimmune Diseases: Implication in Precision Medicine of Autoimmune Diseases

Overview

Journal Precis Clin Med

Publisher Oxford University Press

Specialty General Medicine

Date 2022 Aug 22

PMID 35990897

Authors

Wenjing Yang

Tianming Yu

Yingzi Cong

Affiliations

Soon will be listed here.

Abstract

CD4 T cells are critical to the development of autoimmune disorders. Glucose, fatty acids, and glutamine metabolisms are the primary metabolic pathways in immune cells, including CD4 T cells. The distinct metabolic programs in CD4 T cell subsets are recognized to reflect the bioenergetic requirements, which are compatible with their functional demands. Gut microbiota affects T cell responses by providing a series of antigens and metabolites. Accumulating data indicate that CD4 T cell metabolic pathways underlie aberrant T cell functions, thereby regulating the pathogenesis of autoimmune disorders, including inflammatory bowel diseases, systemic lupus erythematosus, and rheumatoid arthritis. Here, we summarize the current progress of CD4 T cell metabolic programs, gut microbiota regulation of T cell metabolism, and T cell metabolic adaptions to autoimmune disorders to shed light on potential metabolic therapeutics for autoimmune diseases.

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