[Experiences with Timolol in Treatment of Glaucoma (author's Transl)]
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Timolol is a beta-adrenergic blocking agent that produces a significant decrease in intraocular pressure. Timolol ophthalmic solution 0,25% and 0,5% was compared to pilocarpine 1%, 2% and 4% in a randomized, double-masked study involving 40 patients with primary open angle glaucoma or ocular hypertension. Each patient was followed for 6 months. Timolol lowered the 1OP 30% compared to the pretreatment pressure, Pilocarpine 20%. Timolol was well tolerated in general, but 3 patients showed a superficial keratopathy. 30 other glaucoma patients with previously unsufficient pressure control received Timolol alone or in combination with a topical cholinergic agent or/and a systematic carbonic anhydrase inhibitor. The results are presented in detail.
Pharmacological therapy for glaucoma: a review.
Hoyng P, van Beek L Drugs. 2000; 59(3):411-34.
PMID: 10776828 DOI: 10.2165/00003495-200059030-00003.
Timolol eye drops: bradycardia or tachycardia?.
Ros F, Dake C Doc Ophthalmol. 1980; 48(2):283-9.
PMID: 7398530 DOI: 10.1007/BF00141455.
The influence of long-term treatment with timolol on human tear lysozyme albumin content.
Strasser G, Grabner G Graefes Arch Clin Exp Ophthalmol. 1982; 218(2):93-5.
PMID: 7075967 DOI: 10.1007/BF02153718.
Urner-Bloch U, Aeschlimann J, Gloor B Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980; 213(3):175-85.
PMID: 6903108 DOI: 10.1007/BF00410987.
[Timolol and acetazolamide in the treatment of increased intraocular pressure (author's transl)].
Scharrer A, Ober M Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979; 212(2):129-34.
PMID: 317629 DOI: 10.1007/BF00587604.