Non-invasive Brain Temperature Measurement in Acute Ischemic Stroke

Overview

Journal Front Neurol

Specialty Neurology

Date 2022 Aug 22

PMID 35989905

Authors

MacKenzie Horn

William K Diprose

Samuel Pichardo

Andrew Demchuk

Mohammed Almekhlafi

Affiliations

Soon will be listed here.

Abstract

Selective therapeutic hypothermia in the setting of mechanical thrombectomy (MT) is promising to further improve the outcomes of large vessel occlusion stroke. A significant limitation in applying hypothermia in this setting is the lack of real-time non-invasive brain temperature monitoring mechanism. Non-invasive brain temperature monitoring would provide important information regarding the brain temperature changes during cooling, and the factors that might influence any fluctuations. This review aims to provide appraisal of brain temperature changes during stroke, and the currently available non-invasive modalities of brain temperature measurement that have been developed and tested over the past 20 years. We cover modalities including magnetic resonance spectroscopy imaging (MRSI), radiometric thermometry, and microwave radiometry, and the evidence for their accuracy from human and animal studies. We also evaluate the feasibility of using these modalities in the acute stroke setting and potential ways for incorporating brain temperature monitoring in the stroke workflow.

Citing Articles

Model-predicted brain temperature computational imaging by multimodal noninvasive functional neuromonitoring of cerebral oxygen metabolism and hemodynamics: MRI-derived and clinical validation.

Jiang M, Cao F, Zhang Q, Qi Z, Gao Y, Zhang Y J Cereb Blood Flow Metab. 2024; 45(2):275-291.

PMID: 39129194 PMC: 11572106. DOI: 10.1177/0271678X241270485.

Penumbral cooling in ischemic stroke with intraarterial, intravenous or active conductive head cooling: A thermal modeling study.

Diprose W, Rao A, Ghate K, Dyer Z, Campbell D, Almekhlafi M J Cereb Blood Flow Metab. 2023; 44(1):66-76.

PMID: 37734834 PMC: 10905634. DOI: 10.1177/0271678X231203025.

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