Mesenchymal Stem Cells and Their Microenvironment

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2022 Aug 20

PMID 35987711

Authors

Jiaxi Liu

Jinfang Gao

Zixie Liang

Chong Gao

Qing Niu

Fengping Wu

Liyun Zhang

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair. The microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and humoral components. It is also the place for cells' interaction. The stability of the microenvironment is pivotal for maintaining cell proliferation, differentiation, metabolism and functional activities. Abnormal changes in microenvironment components can interfere cell functions. In some diseases, MSCs can interact with the microenvironment and accelerate disease progression. This review will discuss the characteristics of MSCs and their microenvironment, as well as the interaction between MSCs and microenvironment in disease.

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