Human Immunodeficiency Virus in Adults Undergoing Surgery for Brain Tumors

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Aug 18

PMID 35978755

Authors

Lauren Harris

Shahinur Rahman

Mohamed Khoudir

Hu Liang Low

Babar Vaqas

Affiliations

Soon will be listed here.

Abstract

Introduction Early diagnosis and treatment of human immunodeficiency virus (HIV) can improve outcomes. HIV prevalence in brain tumor patients and the impact of an HIV diagnosis on patient outcomes are poorly understood. Materials and methods This was a prospective study of 100 consecutive brain tumor patients admitted to a Greater London Tertiary Neurosurgical center for surgery between January 2021 and October 2021. All brain tumors were included. All patients have appropriately consented. Blood was tested to detect HIV antibodies and p24 antigen. Outcomes were noted at 30-day postoperative follow-up. Results In 100 patients, there was one case of a known HIV-positive, seronegative patient, and no new diagnosis was made, giving a prevalence of 1%. The mean age of patients included was 61.7 ± 13.3, with 57% female. The patient with HIV suffered a postoperative pseudomonas infection, requiring intensive care, additional surgery, and antibiotics. This resulted in an inpatient stay of 55 days - an increase of 274% compared to patients without HIV. Conclusion Literature regarding the prevalence of HIV in glioma patients is inconclusive, of low quality, and primarily out-of-date. Our literature search found no similar study of rates of HIV in brain tumor patients in the United Kingdom. The incidence of both HIV and brain tumors, particularly glioblastomas, is low.

References

Tao Y, Wei Q, Xu Z, Bai R, Li Y, Luo C . Holistic and network analysis of meningioma pathogenesis and malignancy. Biofactors. 2007; 28(3-4):203-19. DOI: 10.1002/biof.5520280307. View

Jokonya L, Musara A, Esene I, Kabulo K, Kabeya C, Kaluile Ntenga Kalangu K . Prevalence of human immunodeficiency virus infection in brain glioma patients: Is the virus protective from gliomas?. Surg Neurol Int. 2018; 9:103. PMC: 5991276. DOI: 10.4103/sni.sni_423_17. View

Henderson D, Sims-Williams H, Wilhelm T, Sims-Williams H, Bhagani S, Thorne L . Neurosurgery and human immunodeficiency virus in the era of combination antiretroviral therapy: a review. J Neurosurg. 2016; 126(3):897-907. DOI: 10.3171/2016.1.JNS151194. View

Hall J, Short S . Management of glioblastoma multiforme in HIV patients: a case series and review of published studies. Clin Oncol (R Coll Radiol). 2009; 21(8):591-7. DOI: 10.1016/j.clon.2009.04.006. View

Singla R, Kamra D, Sharma R, Katiyar V, Gurjar H . Do Gliomas Behave Differently in Patients with Human Immunodeficiency Virus?. World Neurosurg. 2018; 114:431. DOI: 10.1016/j.wneu.2018.03.104. View

Chou R, Huffman L, Fu R, Smits A, Korthuis P . Screening for HIV: a review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2005; 143(1):55-73. DOI: 10.7326/0003-4819-143-1-200507050-00010. View

Ostrom Q, Cote D, Ascha M, Kruchko C, Barnholtz-Sloan J . Adult Glioma Incidence and Survival by Race or Ethnicity in the United States From 2000 to 2014. JAMA Oncol. 2018; 4(9):1254-1262. PMC: 6143018. DOI: 10.1001/jamaoncol.2018.1789. View

Pore N, Gupta A, Cerniglia G, Maity A . HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells. Neoplasia. 2006; 8(11):889-95. PMC: 1716015. DOI: 10.1593/neo.06535. View

Barnes E, Saxon C, Ahmad S . Cancer prevalence in a metropolitan HIV clinic. J Int AIDS Soc. 2014; 17(4 Suppl 3):19651. PMC: 4224773. DOI: 10.7448/IAS.17.4.19651. View

10.

Marcus J, Leyden W, Alexeeff S, Anderson A, Hechter R, Hu H . Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016. JAMA Netw Open. 2020; 3(6):e207954. PMC: 7296391. DOI: 10.1001/jamanetworkopen.2020.7954. View

11.

Blumenthal D, Raizer J, Rosenblum M, Bilsky M, Hariharan S, Abrey L . Primary intracranial neoplasms in patients with HIV. Neurology. 1999; 52(8):1648-51. DOI: 10.1212/wnl.52.8.1648. View

12.

Omar 2nd A, Nepomuceno M, Salvana E, Chua A . Intracranial Mass Lesions in Human Immunodeficiency Virus Patients in the Philippines: A Retrospective Cohort Study. World Neurosurg. 2020; 145:e149-e154. DOI: 10.1016/j.wneu.2020.09.141. View

13.

von Gaudecker J, Oduor C, Ofner S, Oyungu E, Said J, Buelow J . Pattern and frequency of neurological and neurosurgical care of adult inpatients and outpatients at a tertiary referral hospital in Kenya. eNeurologicalSci. 2020; 21:100286. PMC: 7649259. DOI: 10.1016/j.ensci.2020.100286. View

14.

Wang T, Gao T, Niu X, Xing X, Yang Y, Liu Y . Clinical Characteristics and Prognostic Analysis of Glioma in Human Immunodeficiency Virus-Infected Patients. World Neurosurg. 2018; 114:e218-e223. DOI: 10.1016/j.wneu.2018.02.168. View

15.

Choy W, Lagman C, Lee S, Bui T, Safaee M, Yang I . Impact of Human Immunodeficiency Virus in the Pathogenesis and Outcome of Patients with Glioblastoma Multiforme. Brain Tumor Res Treat. 2016; 4(2):77-86. PMC: 5114196. DOI: 10.14791/btrt.2016.4.2.77. View

16.

Ganczak M, Szych Z . Infections with HBV, HCV and HIV in patients admitted to the neurosurgical department of a teaching hospital. Neurol Neurochir Pol. 2008; 42(3):231-7. View