Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2022 Aug 17

PMID 35978229

Authors

Yuan Cheng

Xiaoxuan Wang

Yinghua Yu

Jingxue Gu

Maofang Zhao

Qian Fu

Yilin Song

Yi Liu

Affiliations

Soon will be listed here.

Abstract

Noise is a kind of sound that causes agitation and harms human health. Studies have shown that noise can lead to neuroinflammation, damage to synaptic plasticity and altered levels of neurotransmitters that may result in depression. The present study demonstrated that luteolin exerted antidepressant-like effects by improving neuroinflammation in a mouse model of noise-induced depression. Luteolin significantly alleviated noise-induced depression-like behavior. Notably, luteolin treatment not only remarkably ameliorated noise-induced inflammation in the hippocampus and prefrontal cortex, but also increased synapsin. Furthermore, luteolin treatment significantly increased the contents of serum 5-hydroxytryptamine and norepinephrine in noise-induced mice. In sum, luteolin exerts antidepressant effects indepression-like mice caused by noise, which can serve as a potential agent for the treatment of chronic noise-induced depression.

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References

Babisch W . The Noise/Stress Concept, Risk Assessment and Research Needs. Noise Health. 2003; 4(16):1-11. View

Min J, Min K . Night noise exposure and risk of death by suicide in adults living in metropolitan areas. Depress Anxiety. 2018; 35(9):876-883. DOI: 10.1002/da.22789. View

Seidler A, Hegewald J, Seidler A, Schubert M, Wagner M, Droge P . Association between aircraft, road and railway traffic noise and depression in a large case-control study based on secondary data. Environ Res. 2016; 152:263-271. DOI: 10.1016/j.envres.2016.10.017. View

Hahad O, Prochaska J, Daiber A, Muenzel T . Environmental Noise-Induced Effects on Stress Hormones, Oxidative Stress, and Vascular Dysfunction: Key Factors in the Relationship between Cerebrocardiovascular and Psychological Disorders. Oxid Med Cell Longev. 2019; 2019:4623109. PMC: 6878772. DOI: 10.1155/2019/4623109. View

Graff L, Walker J, Bernstein C . Depression and anxiety in inflammatory bowel disease: a review of comorbidity and management. Inflamm Bowel Dis. 2009; 15(7):1105-18. DOI: 10.1002/ibd.20873. View

Schmidt F, Kirkby K, Lichtblau N . Inflammation and Immune Regulation as Potential Drug Targets in Antidepressant Treatment. Curr Neuropharmacol. 2016; 14(7):674-87. PMC: 5050395. DOI: 10.2174/1570159x14666160115130414. View

Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim E . A meta-analysis of cytokines in major depression. Biol Psychiatry. 2009; 67(5):446-57. DOI: 10.1016/j.biopsych.2009.09.033. View

Cui W, Ning Y, Hong W, Wang J, Liu Z, Li M . Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine's Antidepressant Effect. Mol Neurobiol. 2018; 56(5):3484-3500. DOI: 10.1007/s12035-018-1306-3. View

Black C, Miller B . Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients. Biol Psychiatry. 2014; 78(1):28-37. DOI: 10.1016/j.biopsych.2014.10.014. View

10.

Serafini G, Pompili M, Seretti M, Stefani H, Palermo M, Coryell W . The role of inflammatory cytokines in suicidal behavior: a systematic review. Eur Neuropsychopharmacol. 2013; 23(12):1672-86. DOI: 10.1016/j.euroneuro.2013.06.002. View

11.

Kim Y, Na K, Myint A, Leonard B . The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2015; 64:277-84. DOI: 10.1016/j.pnpbp.2015.06.008. View

12.

Li H, Xiao Y, Han L, Jia Y, Luo S, Zhang D . Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system. Brain Res Bull. 2021; 171:16-24. DOI: 10.1016/j.brainresbull.2021.03.002. View

13.

Robson M, Quinlan M, Blakely R . Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. ACS Chem Neurosci. 2017; 8(5):932-942. DOI: 10.1021/acschemneuro.6b00412. View

14.

Wang S, Yu Y, Feng Y, Zou F, Zhang X, Huang J . Protective effect of the orientin on noise-induced cognitive impairments in mice. Behav Brain Res. 2015; 296:290-300. DOI: 10.1016/j.bbr.2015.09.024. View

15.

Zhao Y, Wang Q, Jia M, Fu S, Pan J, Chu C . (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation. J Nutr Biochem. 2018; 64:61-71. DOI: 10.1016/j.jnutbio.2018.10.006. View

16.

Bus B, Molendijk M, Tendolkar I, Penninx B, Prickaerts J, Elzinga B . Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time. Mol Psychiatry. 2014; 20(5):602-8. DOI: 10.1038/mp.2014.83. View

17.

Dwivedi Y, Rizavi H, Conley R, Roberts R, Tamminga C, Pandey G . Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry. 2003; 60(8):804-15. DOI: 10.1001/archpsyc.60.8.804. View

18.

Russo-Neustadt A . Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders. Semin Clin Neuropsychiatry. 2003; 8(2):109-18. DOI: 10.1053/scnp.2003.50014. View

19.

Pivac N, Kozaric-Kovacic D, Grubisic-Ilic M, Nedic G, Rakos I, Nikolac M . The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder. World J Biol Psychiatry. 2011; 13(4):306-11. DOI: 10.3109/15622975.2011.582883. View

20.

Li N, Lee B, Liu R, Banasr M, Dwyer J, Iwata M . mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010; 329(5994):959-64. PMC: 3116441. DOI: 10.1126/science.1190287. View