Ability of a Modified Sequential Organ Failure Assessment Score to Predict Mortality Among Sepsis Patients in a Resource-limited Setting

Overview

Journal Acute Crit Care

Specialty Critical Care

Date 2022 Aug 17

PMID 35977902

Authors

Bodin Khwannimit

Rungsun Bhurayanontachai

Veerapong Vattanavanit

Affiliations

Soon will be listed here.

Abstract

Background: Some variables of the Sequential Organ Failure Assessment (SOFA) score are not routinely measured in sepsis patients, especially in countries with limited resources. Therefore, this study was conducted to evaluate the accuracy of the modified SOFA (mSOFA) and compared its ability to predict mortality in sepsis patients to that of the original SOFA score.

Methods: Sepsis patients admitted to the medical intensive care unit of Songklanagarind Hospital between 2011 and 2018 were retrospectively analyzed. The primary outcome was all-cause in-hospital mortality.

Results: A total of 1,522 sepsis patients were enrolled. The mean SOFA and mSOFA scores were 9.7±4.3 and 8.8±3.9, respectively. The discrimination of the mSOFA score was significantly higher than that of the SOFA score for all-cause in-hospital mortality (area under the receiver operating characteristic curve, 0.891 [95% confidence interval, 0.875-0.907] vs. 0.879 [0.862-0.896]; P<0.001), all-cause intensive care unit (ICU) mortality (0.880 [0.863-0.898] vs. 0.871 [0.853-0.889], P=0.01) and all-cause 28-day mortality (0.887 [0.871-0.904] vs. 0.874 [0.856-0.892], P<0.001). The ability of mSOFA score to predict all-cause in-hospital and 28-day mortality was higher than that of the SOFA score within the subgroups of sepsis according to age, sepsis severity and serum lactate levels. The mSOFA score was demonstrated to have a performance similar to the original SOFA score regarding the prediction of mortality in sepsis patients with cirrhosis or hepatic dysfunction.

Conclusions: The mSOFA score was a good alternative to the original SOFA core in predicting mortality among sepsis patients admitted to the ICU.

Citing Articles

SOFA in sepsis: with or without GCS.

Wang L, Ma X, Zhou G, Gao S, Pan W, Chen J Eur J Med Res. 2024; 29(1):296.

PMID: 38790024 PMC: 11127461. DOI: 10.1186/s40001-024-01849-w.

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