Current Advancements and Future Perspectives of Long Noncoding RNAs in Lipid Metabolism and Signaling

Overview

Journal J Adv Res

Specialties General Medicine
Science

Date 2022 Aug 16

PMID 35973552

Authors

Jiufei Duan

Zhao Huang

Edouard C Nice

Na Xie

Mingqing Chen

Canhua Huang

Affiliations

Soon will be listed here.

Abstract

Background: The investigation of lncRNAs has provided a novel perspective for elucidating mechanisms underlying diverse physiological and pathological processes. Compelling evidence has revealed an intrinsic link between lncRNAs and lipid metabolism, demonstrating that lncRNAs-induced disruption of lipid metabolism and signaling contribute to the development of multiple cancers and some other diseases, including obesity, fatty liver disease, and cardiovascular disease.

Aimof Review: The current review summarizes the recent advances in basic research about lipid metabolism and lipid signaling-related lncRNAs. Meanwhile, the potential and challenges of targeting lncRNA for the therapy of cancers and other lipid metabolism-related diseases are also discussed.

Key Scientific Concept Of Review: Compared with the substantial number of lncRNA loci, we still know little about the role of lncRNAs in metabolism. A more comprehensive understanding of the function and mechanism of lncRNAs may provide a new standpoint for the study of lipid metabolism and signaling. Developing lncRNA-based therapeutic approaches is an effective strategy for lipid metabolism-related diseases.

Citing Articles

The Role of Selected lncRNAs in Lipid Metabolism and Cardiovascular Disease Risk.

Gluba-Sagr A, Franczyk B, Rysz-Gorzynska A, Olszewski R, Rysz J Int J Mol Sci. 2024; 25(17).

PMID: 39273193 PMC: 11395304. DOI: 10.3390/ijms25179244.

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma.

Wang R, Yang J, Xu N, Xu J, Yang S, Liang D World J Gastroenterol. 2024; 30(8):919-942.

PMID: 38516243 PMC: 10950635. DOI: 10.3748/wjg.v30.i8.919.

LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer.

Hu Y, Hu Y, Lu X, Luo H, Chen Z J Cancer. 2024; 15(8):2179-2192.

PMID: 38495499 PMC: 10937278. DOI: 10.7150/jca.93820.

Long non‑coding RNAs, lipid metabolism and cancer (Review).

Zhang Z, Hou X, Cao X, Wang X Exp Ther Med. 2023; 26(4):470.

PMID: 37664674 PMC: 10468807. DOI: 10.3892/etm.2023.12169.

Roles of long non-coding RNAs in digestive tract cancer and their clinical application.

Zhang Z, Wang X Zhejiang Da Xue Xue Bao Yi Xue Ban. 2023; 52(4):451-459.

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References

Schnitzbauer A, Filmann N, Adam R, Bachellier P, Bechstein W, Becker T . mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors. Ann Surg. 2020; 272(5):855-862. DOI: 10.1097/SLA.0000000000004280. View

Hong D, Kurzrock R, Kim Y, Woessner R, Younes A, Nemunaitis J . AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer. Sci Transl Med. 2015; 7(314):314ra185. PMC: 5279222. DOI: 10.1126/scitranslmed.aac5272. View

Luo J, Yang H, Song B . Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2019; 21(4):225-245. DOI: 10.1038/s41580-019-0190-7. View

Wang K, Chang H . Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011; 43(6):904-14. PMC: 3199020. DOI: 10.1016/j.molcel.2011.08.018. View

Qin W, Li X, Xie L, Li S, Liu J, Jia L . A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice. Nucleic Acids Res. 2016; 44(13):6423-33. PMC: 5291254. DOI: 10.1093/nar/gkw341. View

Zhao X, Lin J . Long Noncoding RNAs: A New Regulatory Code in Metabolic Control. Trends Biochem Sci. 2015; 40(10):586-596. PMC: 4584418. DOI: 10.1016/j.tibs.2015.08.002. View

Berglund L, Brunzell J, Goldberg A, Goldberg I, Sacks F, Murad M . Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012; 97(9):2969-89. PMC: 3431581. DOI: 10.1210/jc.2011-3213. View

Mitchel K, Theusch E, Cubitt C, Dose A, Stevens K, Naidoo D . RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol. Circ Cardiovasc Genet. 2016; 9(3):223-30. PMC: 4917428. DOI: 10.1161/CIRCGENETICS.115.001274. View

Li X, Shen L, Hua T, Liu Z . Structural and Functional Insights into Cannabinoid Receptors. Trends Pharmacol Sci. 2020; 41(9):665-677. DOI: 10.1016/j.tips.2020.06.010. View

10.

Mutlu A, Duffy J, Wang M . Lipid metabolism and lipid signals in aging and longevity. Dev Cell. 2021; 56(10):1394-1407. PMC: 8173711. DOI: 10.1016/j.devcel.2021.03.034. View

11.

Hotamisligil G, Bernlohr D . Metabolic functions of FABPs--mechanisms and therapeutic implications. Nat Rev Endocrinol. 2015; 11(10):592-605. PMC: 4578711. DOI: 10.1038/nrendo.2015.122. View

12.

Lim S, Wei J, Nguyen T, Shi H, Su W, Palacios G . Lipid signalling enforces functional specialization of T cells in tumours. Nature. 2021; 591(7849):306-311. PMC: 8168716. DOI: 10.1038/s41586-021-03235-6. View

13.

Ma D, Yuan L, Lin L . LncRNA HOTAIR contributes to the tumorigenesis of nasopharyngeal carcinoma via up-regulating FASN. Eur Rev Med Pharmacol Sci. 2017; 21(22):5143-5152. DOI: 10.26355/eurrev_201711_13831. View

14.

Knipe R, Spinney J, Abe E, Probst C, Franklin A, Logue A . Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2021; 66(1):38-52. PMC: 8803357. DOI: 10.1165/rcmb.2020-0408OC. View

15.

Takahashi N, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y . TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P₂. Nat Commun. 2014; 5:4994. DOI: 10.1038/ncomms5994. View

16.

Dong Z, Li C, Yin C, Xu M, Liu S, Gao M . LncRNA PU.1 AS regulates arsenic-induced lipid metabolism through EZH2/Sirt6/SREBP-1c pathway. J Environ Sci (China). 2019; 85:138-146. DOI: 10.1016/j.jes.2019.05.019. View

17.

Yuan Z, Huang W . New Developments in Exosomal lncRNAs in Cardiovascular Diseases. Front Cardiovasc Med. 2021; 8:709169. PMC: 8295603. DOI: 10.3389/fcvm.2021.709169. View

18.

Sukocheva O, Furuya H, Ng M, Friedemann M, Menschikowski M, Tarasov V . Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target. Pharmacol Ther. 2019; 207:107464. DOI: 10.1016/j.pharmthera.2019.107464. View

19.

Liu X, Liang Y, Song R, Yang G, Han J, Lan Y . Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation. Mol Cancer. 2018; 17(1):90. PMC: 5953401. DOI: 10.1186/s12943-018-0838-5. View

20.

Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H . A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice. Cell Metab. 2015; 21(3):455-67. PMC: 4350020. DOI: 10.1016/j.cmet.2015.02.004. View