Studies on Phytohemagglutinin-induced Peritonitis of Mice: Dynamics of Inflammatory Responses and Influence of Anticomplementary Agents and Anti-inflammatory Drugs
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The intraperitoneal injection of phytohemagglutinin in the mouse resulted in the marked accumulation of leukocytes, especially macrophages, in the peritoneal cavity between 8 and 36 h after the injection. Parallel to the accumulation of macrophages, exudation of plasma proteins into the peritoneal cavity was observed. When the effect of anticomplementary agents (FUT-175 and K-76 COONa) and anti-inflammatory drugs (indomethacin and dexamethasone) on phytohemagglutinin-induced peritonitis was examined, FUT-175, K-76 COONa and indomethacin suppressed only the plasma protein exudation. On the other hand, dexamethasone suppressed both the accumulation of macrophages and the plasma protein exudation.
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