Multitarget High-definition Transcranial Direct Current Stimulation Improves Response Inhibition More Than Single-target High-definition Transcranial Direct Current Stimulation in Healthy Participants

Overview

Journal Front Neurosci

Date 2022 Aug 15

PMID 35968393

Authors

Zhihua Guo

Yue Gong

Hongliang Lu

Rui Qiu

Xinlu Wang

Xia Zhu

Xuqun You

Affiliations

Soon will be listed here.

Abstract

Prior studies have focused on single-target anodal transcranial direct current stimulation (tDCS) over the right inferior frontal gyrus (rIFG) or pre-supplementary motor area (pre-SMA) to improve response inhibition in healthy individuals. However, the results are contradictory and the effect of multitarget anodal stimulation over both brain regions has never been investigated. The present study aimed to investigate the behavioral and neurophysiological effects of different forms of anodal high-definition tDCS (HD-tDCS) on improving response inhibition, including HD-tDCS over the rIFG or pre-SMA and multitarget HD-tDCS over both areas. Ninety-two healthy participants were randomly assigned to receive single-session (20 min) anodal HD-tDCS over rIFG + pre-SMA, rIFG, pre-SMA, or sham stimulation. Before and immediately after tDCS intervention, participants completed a stop-signal task (SST) and a go/nogo task (GNG). Their cortical activity was recorded using functional near-infrared spectroscopy (fNIRS) during the go/nogo task. The results showed multitarget stimulation produced a significant reduction in stop-signal reaction time (SSRT) relative to baseline. The pre-to-post SSRT change was not significant for rIFG, pre-SMA, or sham stimulation. Further analyses revealed multitarget HD-tDCS significantly decreased SSRT in both the high-performance and low-performance subgroups compared with the rIFG condition which decreased SSRT only in the low-performance subgroup. Only the multitarget condition significantly improved neural efficiency as indexed by lower △oxy-Hb after stimulation. In conclusion, the present study provides important preliminary evidence that multitarget HD-tDCS is a promising avenue to improve stimulation efficacy, establishing a more effective montage to enhance response inhibition relative to the commonly used single-target stimulation.

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References

Yu J, Tseng P, Hung D, Wu S, Juan C . Brain stimulation improves cognitive control by modulating medial-frontal activity and preSMA-vmPFC functional connectivity. Hum Brain Mapp. 2015; 36(10):4004-15. PMC: 6869595. DOI: 10.1002/hbm.22893. View

Hill A, Rogasch N, Fitzgerald P, Hoy K . Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects. Brain Stimul. 2018; 11(5):1033-1043. DOI: 10.1016/j.brs.2018.06.005. View

Jacobson L, Javitt D, Lavidor M . Activation of inhibition: diminishing impulsive behavior by direct current stimulation over the inferior frontal gyrus. J Cogn Neurosci. 2011; 23(11):3380-7. DOI: 10.1162/jocn_a_00020. View

Abellaneda-Perez K, Vaque-Alcazar L, Perellon-Alfonso R, Sole-Padulles C, Bargallo N, Salvador R . Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density. Front Aging Neurosci. 2021; 13:725013. PMC: 8662695. DOI: 10.3389/fnagi.2021.725013. View

Dambacher F, Schuhmann T, Lobbestael J, Arntz A, Brugman S, Sack A . No Effects of Bilateral tDCS over Inferior Frontal Gyrus on Response Inhibition and Aggression. PLoS One. 2015; 10(7):e0132170. PMC: 4498781. DOI: 10.1371/journal.pone.0132170. View

Alderson R, Patros C, Tarle S, Hudec K, Kasper L, Lea S . [Formula: see text]Working memory and behavioral inhibition in boys with ADHD: An experimental examination of competing models. Child Neuropsychol. 2015; 23(3):255-272. DOI: 10.1080/09297049.2015.1105207. View

Sun Q, Fang Y, Shi Y, Wang L, Peng X, Tan L . Inhibitory Top-Down Control Deficits in Schizophrenia With Auditory Verbal Hallucinations: A Go/NoGo Task. Front Psychiatry. 2021; 12:544746. PMC: 8211872. DOI: 10.3389/fpsyt.2021.544746. View

Yeh C, Gau S, Kessler R, Wu Y . Psychometric properties of the Chinese version of the adult ADHD Self-report Scale. Int J Methods Psychiatr Res. 2008; 17(1):45-54. PMC: 6878254. DOI: 10.1002/mpr.241. View

Ester T, Kullmann S . Neurobiological regulation of eating behavior: Evidence based on non-invasive brain stimulation. Rev Endocr Metab Disord. 2021; 23(4):753-772. PMC: 9307556. DOI: 10.1007/s11154-021-09697-3. View

10.

Bartholdy S, ODaly O, Campbell I, Banaschewski T, Barker G, Bokde A . Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents. Biol Psychiatry. 2019; 85(11):956-965. DOI: 10.1016/j.biopsych.2019.01.027. View

11.

Maldonado T, Bernard J . The Polarity-Specific Nature of Single-Session High-definition Transcranial Direct Current Stimulation to the Cerebellum and Prefrontal Cortex on Motor and Non-motor Task Performance. Cerebellum. 2021; 20(4):569-583. DOI: 10.1007/s12311-021-01235-w. View

12.

Stramaccia D, Penolazzi B, Sartori G, Braga M, Mondini S, Galfano G . Assessing the effects of tDCS over a delayed response inhibition task by targeting the right inferior frontal gyrus and right dorsolateral prefrontal cortex. Exp Brain Res. 2015; 233(8):2283-90. DOI: 10.1007/s00221-015-4297-6. View

13.

Fischer D, Fried P, Ruffini G, Ripolles O, Salvador R, Banus J . Multifocal tDCS targeting the resting state motor network increases cortical excitability beyond traditional tDCS targeting unilateral motor cortex. Neuroimage. 2017; 157:34-44. DOI: 10.1016/j.neuroimage.2017.05.060. View

14.

Bikson M, Grossman P, Thomas C, Zannou A, Jiang J, Adnan T . Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016. Brain Stimul. 2016; 9(5):641-661. PMC: 5007190. DOI: 10.1016/j.brs.2016.06.004. View

15.

Hughes M, Fulham W, Johnston P, Michie P . Stop-signal response inhibition in schizophrenia: behavioural, event-related potential and functional neuroimaging data. Biol Psychol. 2011; 89(1):220-31. DOI: 10.1016/j.biopsycho.2011.10.013. View

16.

Ye J, Tak S, Jang K, Jung J, Jang J . NIRS-SPM: statistical parametric mapping for near-infrared spectroscopy. Neuroimage. 2008; 44(2):428-47. DOI: 10.1016/j.neuroimage.2008.08.036. View

17.

Zhuo L, Zhao X, Zhai Y, Zhao B, Tian L, Zhang Y . Transcutaneous electrical acupoint stimulation for children with attention-deficit/hyperactivity disorder: a randomized clinical trial. Transl Psychiatry. 2022; 12(1):165. PMC: 9022403. DOI: 10.1038/s41398-022-01914-0. View

18.

Cunillera T, Brignani D, Cucurell D, Fuentemilla L, Miniussi C . The right inferior frontal cortex in response inhibition: A tDCS-ERP co-registration study. Neuroimage. 2015; 140:66-75. DOI: 10.1016/j.neuroimage.2015.11.044. View

19.

Enge S, Behnke A, Fleischhauer M, Kuttler L, Kliegel M, Strobel A . No evidence for true training and transfer effects after inhibitory control training in young healthy adults. J Exp Psychol Learn Mem Cogn. 2014; 40(4):987-1001. DOI: 10.1037/a0036165. View

20.

Tsuzuki D, Jurcak V, Singh A, Okamoto M, Watanabe E, Dan I . Virtual spatial registration of stand-alone fNIRS data to MNI space. Neuroimage. 2007; 34(4):1506-18. DOI: 10.1016/j.neuroimage.2006.10.043. View