Molecular Basis of Acute Coronary Syndrome

Overview

Journal J Res Med Sci

Specialty General Medicine

Date 2022 Aug 15

PMID 35968216

Authors

Natalya Balashkevich

Maxut Kazymov

Marat Syzdykbayev

Aima Adylova

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases (CVD) comprise of various heart and blood vessels-related diseases. Acute coronary syndrome (ACS) is one of them. Basic researchers and cardiologists have witnessed landmark developments related to ACS and despite rapid refinement in our understanding; scientists are seeking answers for more questions. Scientists have mapped wide ranging proteins and intricate protein networks which play central role in the pathogenesis in ACS. In this review, we have attempted to summarize underlying causes of ACS. Better understanding of the disease pathology will enable us to get a step closer to an effective clinical management.

Citing Articles

Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.

Blascakova M, Hricova K, Maslejova K, Majherova M, Vaskova H, Poracova J Cent Eur J Public Health. 2024; 31(Suppl 1):S75-S81.

PMID: 38272484 DOI: 10.21101/cejph.a7843.

References

Yu J, Li Y, Leng D, Cao C, Yu Y, Wang Y . microRNA-3646 serves as a diagnostic marker and mediates the inflammatory response induced by acute coronary syndrome. Bioengineered. 2021; 12(1):5632-5640. PMC: 8806520. DOI: 10.1080/21655979.2021.1967066. View

Surendran A, Atefi N, Zhang H, Aliani M, Ravandi A . Defining Acute Coronary Syndrome through Metabolomics. Metabolites. 2021; 11(10). PMC: 8540033. DOI: 10.3390/metabo11100685. View

Reid G, Kirschner M, van Zandwijk N . Circulating microRNAs: Association with disease and potential use as biomarkers. Crit Rev Oncol Hematol. 2010; 80(2):193-208. DOI: 10.1016/j.critrevonc.2010.11.004. View

Su Q, Li L, Sun Y, Yang H, Ye Z, Zhao J . Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury. Cell Physiol Biochem. 2018; 47(4):1497-1508. DOI: 10.1159/000490866. View

Wolsk E, Claggett B, Diaz R, Dickstein K, Gerstein H, Kober L . Increases in Natriuretic Peptides Precede Heart Failure Hospitalization in Patients With a Recent Coronary Event and Type 2 Diabetes Mellitus. Circulation. 2017; 136(16):1560-1562. DOI: 10.1161/CIRCULATIONAHA.117.029503. View

Parsamanesh N, Moossavi M, Bahrami A, Fereidouni M, Barreto G, Sahebkar A . NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy. Int Immunopharmacol. 2019; 73:146-155. DOI: 10.1016/j.intimp.2019.05.006. View

Zhao B, Zhang Z, Gui L, Xiang Y, Sun X, Huang L . MiR-let-7i inhibits CD4+ T cell apoptosis in patients with acute coronary syndrome. Adv Clin Exp Med. 2021; 30(8):779-788. DOI: 10.17219/acem/135937. View

Pagidipati N, Peterson E . Acute coronary syndromes in women and men. Nat Rev Cardiol. 2016; 13(8):471-80. PMC: 9755956. DOI: 10.1038/nrcardio.2016.89. View

Martinez G, Robertson S, Barraclough J, Xia Q, Mallat Z, Bursill C . Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome. J Am Heart Assoc. 2015; 4(8):e002128. PMC: 4599469. DOI: 10.1161/JAHA.115.002128. View

10.

Goodacre S, Locker T, Morris F, Campbell S . How useful are clinical features in the diagnosis of acute, undifferentiated chest pain?. Acad Emerg Med. 2002; 9(3):203-8. DOI: 10.1111/j.1553-2712.2002.tb00245.x. View

11.

Gidron Y, Gilutz H, Berger R, Huleihel M . Molecular and cellular interface between behavior and acute coronary syndromes. Cardiovasc Res. 2002; 56(1):15-21. DOI: 10.1016/s0008-6363(02)00537-0. View

12.

Li Y, Wang X, Li B, Liu K, Qi J, Liu B . Tongxinluo inhibits cyclooxygenase-2, inducible nitric oxide synthase, hypoxia-inducible factor-2α/vascular endothelial growth factor to antagonize injury in hypoxia-stimulated cardiac microvascular endothelial cells. Chin Med J (Engl). 2015; 128(8):1114-20. PMC: 4832955. DOI: 10.4103/0366-6999.155119. View

13.

Niyonzima N, Bakke S, Gregersen I, Holm S, Sandanger O, Orrem H . Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis. EBioMedicine. 2020; 60:102985. PMC: 7494683. DOI: 10.1016/j.ebiom.2020.102985. View

14.

Shen Z, Chen T, Deng B, Fan M, Hua J, Zhang M . Effects on Suxiao Jiuxin Pills in the Treatment of Patients with Acute Coronary Syndrome Undergoing Early Percutaneous Coronary Intervention: A Multicenter Randomized Double-Blind Placebo-Controlled Trial. J Altern Complement Med. 2020; 26(11):1055-1063. DOI: 10.1089/acm.2020.0014. View

15.

McCune C, Maynard S, McClements B, Lindsay J . HbA1c for Diabetes Screening in Acute Coronary Syndrome: time for a reappraisal of the guidelines?. Ulster Med J. 2015; 84(3):154-6. PMC: 4642257. View

16.

Farooqi A, Attar R, Yulaevna I, Berardi R . Interaction of long non-coding RNAs and circular RNAs with microRNAs for the regulation of immunological responses in human cancers. Semin Cell Dev Biol. 2021; 124:63-71. DOI: 10.1016/j.semcdb.2021.05.029. View

17.

Jafarizade M, Kahe F, Sharfaei S, Momenzadeh K, Pitliya A, Tajrishi F . The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review. Cardiology. 2021; 146(4):517-530. DOI: 10.1159/000515359. View

18.

McCarthy B, Wong J, Selker H . Detecting acute cardiac ischemia in the emergency department: a review of the literature. J Gen Intern Med. 1990; 5(4):365-73. DOI: 10.1007/BF02600409. View

19.

Khraiwesh B, Arif M, Seumel G, Ossowski S, Weigel D, Reski R . Transcriptional control of gene expression by microRNAs. Cell. 2010; 140(1):111-22. DOI: 10.1016/j.cell.2009.12.023. View

20.

Gurbel P, Bliden K, Hiatt B, OConnor C . Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003; 107(23):2908-13. DOI: 10.1161/01.CIR.0000072771.11429.83. View