Potential Roles of Non-lymphocytic Cells in the Pathogenesis of IgG4-related Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Aug 15

PMID 35967331

Authors

Shaozhe Cai

Ziwei Hu

Yu Chen

Jixin Zhong

Lingli Dong

Affiliations

Soon will be listed here.

Abstract

Studies have confirmed the involvement of a variety of lymphocyte subsets, including type 2 helper T lymphocytes (Th2) and IgG4 B lymphocytes, in the pathogenesis of IgG4-related disease (IgG4-RD). Those lymphocytes contribute to the major pathogenetic features of IgG4-RD. However, they are not the only cellular components in the immunoinflammatory environment of this mysterious disease entity. Recent studies have suggested that various non-lymphocytic components, including macrophages and fibroblasts, may also play an important role in the pathogenetic process of IgG4-RD in terms of contributing to the chronic and complex progress of the disease. Therefore, the potential role of non-lymphocyte in the pathogenesis of IgG4-RD is worth discussing.

Citing Articles

Unraveling the Clinical Features and Outcomes of IgG4-Related Ophthalmic Disease.

Kim D, Jeong S, Lew H J Clin Med. 2024; 13(13).

PMID: 38999348 PMC: 11242082. DOI: 10.3390/jcm13133780.

Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease.

Tanaka S, Yamamoto T, Iwata A, Kiuchi M, Kokubo K, Iinuma T Arthritis Res Ther. 2024; 26(1):55.

PMID: 38378635 PMC: 10877852. DOI: 10.1186/s13075-024-03289-7.

Wei Q, Qi H, Wei H, Wang X, Zhang H Front Immunol. 2024; 14:1285822.

PMID: 38187395 PMC: 10766768. DOI: 10.3389/fimmu.2023.1285822.

A Unique Adverse Event of Radiotherapy in a Patient With IgG4-related Disease: A Case Report.

Aimi H, Murai T, Takino K, Naito W, Miura I, Hata M In Vivo. 2023; 37(6):2840-2844.

PMID: 37905644 PMC: 10621432. DOI: 10.21873/invivo.13399.

References

Weyand C, Goronzy J . The immunology of rheumatoid arthritis. Nat Immunol. 2020; 22(1):10-18. PMC: 8557973. DOI: 10.1038/s41590-020-00816-x. View

Akiyama M, Yasuoka H, Yoshimoto K, Takeuchi T . CC-chemokine ligand 18 is a useful biomarker associated with disease activity in IgG4-related disease. Ann Rheum Dis. 2017; 77(9):1386-1387. PMC: 6104677. DOI: 10.1136/annrheumdis-2017-212110. View

Stone K, Prussin C, Metcalfe D . IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2010; 125(2 Suppl 2):S73-80. PMC: 2847274. DOI: 10.1016/j.jaci.2009.11.017. View

Jarrell J, Baker M, Perugino C, Liu H, Bloom M, Maehara T . Neutralizing anti-IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease. J Allergy Clin Immunol. 2021; 149(1):358-368. PMC: 8573062. DOI: 10.1016/j.jaci.2021.05.002. View

Maehara T, Moriyama M, Nakashima H, Miyake K, Hayashida J, Tanaka A . Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. Ann Rheum Dis. 2012; 71(12):2011-19. DOI: 10.1136/annrheumdis-2012-201477. View

Kawakami T, Mizushima I, Yamada K, Fujii H, Ito K, Yasuno T . Abundant a proliferation-inducing ligand (APRIL)-producing macrophages contribute to plasma cell accumulation in immunoglobulin G4-related disease. Nephrol Dial Transplant. 2018; 34(6):960-969. PMC: 6545467. DOI: 10.1093/ndt/gfy296. View

Lott J, Sumpter T, Turnquist H . New dog and new tricks: evolving roles for IL-33 in type 2 immunity. J Leukoc Biol. 2015; 97(6):1037-48. DOI: 10.1189/jlb.3RI1214-595R. View

Della-Torre E, Rigamonti E, Perugino C, Baghai-Sain S, Sun N, Kaneko N . B lymphocytes directly contribute to tissue fibrosis in patients with IgG-related disease. J Allergy Clin Immunol. 2019; 145(3):968-981.e14. PMC: 6960365. DOI: 10.1016/j.jaci.2019.07.004. View

Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T . Pathogenicity of IgG in patients with IgG4-related disease. Gut. 2016; 65(8):1322-32. DOI: 10.1136/gutjnl-2015-310336. View

10.

Dufour A, Alvarez M, Russo B, Chizzolini C . Interleukin-6 and Type-I Collagen Production by Systemic Sclerosis Fibroblasts Are Differentially Regulated by Interleukin-17A in the Presence of Transforming Growth Factor-Beta 1. Front Immunol. 2018; 9:1865. PMC: 6099180. DOI: 10.3389/fimmu.2018.01865. View

11.

Wallace Z, Deshpande V, Mattoo H, Mahajan V, Kulikova M, Pillai S . IgG4-Related Disease: Clinical and Laboratory Features in One Hundred Twenty-Five Patients. Arthritis Rheumatol. 2015; 67(9):2466-75. PMC: 4621270. DOI: 10.1002/art.39205. View

12.

Dorrier C, Aran D, Haenelt E, Sheehy R, Hoi K, Pintaric L . CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci. 2021; 24(2):234-244. PMC: 7877789. DOI: 10.1038/s41593-020-00770-9. View

13.

Chen Y, Lin W, Yang H, Wang M, Zhang P, Feng R . Aberrant Expansion and Function of Follicular Helper T Cell Subsets in IgG4-Related Disease. Arthritis Rheumatol. 2018; 70(11):1853-1865. PMC: 6220938. DOI: 10.1002/art.40556. View

14.

Bal S, Golebski K, Spits H . Plasticity of innate lymphoid cell subsets. Nat Rev Immunol. 2020; 20(9):552-565. DOI: 10.1038/s41577-020-0282-9. View

15.

Zhang P, Liu Z, Peng L, Zhou J, Wang M, Li J . Phenotype, function and clinical significance of innate lymphoid cells in immunoglobulin G4-related disease. Rheumatology (Oxford). 2021; 61(5):2197-2209. DOI: 10.1093/rheumatology/keab610. View

16.

Lin W, Jin L, Chen H, Wu Q, Fei Y, Zheng W . B cell subsets and dysfunction of regulatory B cells in IgG4-related diseases and primary Sjögren's syndrome: the similarities and differences. Arthritis Res Ther. 2014; 16(3):R118. PMC: 4075418. DOI: 10.1186/ar4571. View

17.

Lanzillotta M, Mancuso G, Della-Torre E . Advances in the diagnosis and management of IgG4 related disease. BMJ. 2020; 369:m1067. DOI: 10.1136/bmj.m1067. View

18.

Kato H, Endres J, Fox D . The roles of IFN-γ versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts. Mod Rheumatol. 2013; 23(6):1140-50. PMC: 3710715. DOI: 10.1007/s10165-012-0811-x. View

19.

Yamada K, Zuka M, Ito K, Mizuguchi K, Kakuchi Y, Onoe T . LatY136F knock-in mouse model for human IgG4-related disease. PLoS One. 2018; 13(6):e0198417. PMC: 6002065. DOI: 10.1371/journal.pone.0198417. View

20.

Soyfoo M, Nicaise C . Pathophysiologic role of Interleukin-33/ST2 in Sjögren's syndrome. Autoimmun Rev. 2021; 20(3):102756. DOI: 10.1016/j.autrev.2021.102756. View