The Role of Leptin in Systemic Lupus Erythematosus: Is It Still a Mystery?

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Aug 15

PMID 35967162

Authors

Nicole Villa

Omar Badla

Raman Goit

Samia E Saddik

Sarah N Dawood

Ahmad M Rabih

Ahmad Mohammed

Aishwarya Raman

Manish Uprety

Maria Jose Calero

Maria Resah B Villanueva

Narges Joshaghani

Lubna Mohammed

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory connective tissue disease with varying clinical manifestations. Recent studies have proposed that leptin may be related to SLE development. This study aims to assess current information regarding the relationship between leptin and SLE. A systematic search was done using PubMed, Google Scholar, ScienceDirect, Epistemonikos, and Cochrane Library databases. Studies published in the English language in the last 10 years were selected based on predefined eligibility criteria. The quality of the studies was evaluated using the Newcastle-Ottawa Scale and the Assessment of Multiple Systematic Reviews 2 tool. A total of 12 studies were included in this systematic review. These included systematic reviews/meta-analyses, cross-sectional studies, and case-control studies Based on the findings of this review, we conclude thatleptin is significantly elevated in SLE patients; however, it does not seem to correlate with disease activity. The exact mechanism of leptin in the pathogenesis of the disease remains unknown and further research is needed regarding this aspect.

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