Shared and Distinct Patterns of Dynamical Degree Centrality in Bipolar Disorder Across Different Mood States

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2022 Aug 15

PMID 35966464

Authors

Fuping Sun

Zhening Liu

Jun Yang

Zebin Fan

Chang Xi

Peng Cheng

Zhong He

Jie Yang

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have probed the brain static activity pattern in bipolar disorder across different states. However, human intrinsic brain activity is time-varying and dynamic. There is a lack of knowledge about the brain dynamical pattern in bipolar disorder across different mood states.

Methods: This study used the dynamical degree centrality (dDC) to investigate the resting-state whole-brain dynamical pattern voxel-wise in a total of 62 bipolar disorder [28 bipolar depression (BD), 13 bipolar mania (BM), 21 bipolar euthymia (BE)], and 30 healthy controls (HCs). One-way analysis of variance (ANOVA) was applied to explore the omnibus differences of the dDC pattern across all groups, and Pearson's correlation analysis was used to evaluate the relationship between the dDC variability in detected regions with clinical symptom severity.

Results: One-way ANOVA analysis showed the omnibus differences in the left inferior parietal lobule/middle occipital gyrus (IPL/MOG) and right precuneus/posterior cingulate cortex (PCUN/PCC) across all groups. The analysis revealed that BD showed decreased dDC in the IPL/MOG compared with all other groups, and both BD and BM exhibited decreased dDC in the PCUN/PCC compared with BE and HCs. Furthermore, correlation analysis showed that the dDC variability of the IPL/MOG and PCUN/PCC negatively correlated with the depression symptom levels in all patients with bipolar disorder.

Conclusion: This study demonstrated the distinct and shared brain dynamical pattern of the depressive, manic, and euthymia states. Our findings provide new insights into the pathophysiology of bipolar disorder across different mood states from the dynamical brain network pattern perspective.

Citing Articles

Transdiagnostic study of dynamic brain activity and connectivity among people with gambling and internet gaming disorders: DYNAMIC BRAIN ACTIVITY IN GD AND IGD.

Zhou H, He Y, Liu L, Yin J, Xiong A, Leong K Int J Clin Health Psychol. 2025; 25(1):100547.

PMID: 39944189 PMC: 11815891. DOI: 10.1016/j.ijchp.2025.100547.

Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients.

Li H, Wu Q, Wang J, Zhang X, Song H, Wang D BMC Psychiatry. 2024; 24(1):963.

PMID: 39741246 PMC: 11686892. DOI: 10.1186/s12888-024-06427-2.

Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging.

Qiu L, Liang C, Kochunov P, Hutchison K, Sui J, Jiang R Transl Psychiatry. 2024; 14(1):326.

PMID: 39112461 PMC: 11306356. DOI: 10.1038/s41398-024-03035-2.

Aberrant brain dynamics in major depressive disorder during working memory task.

Sun F, Liu Z, Yang J, Fan Z, Wang F, Yang J Eur Arch Psychiatry Clin Neurosci. 2024; .

PMID: 38976050 DOI: 10.1007/s00406-024-01854-4.

Discriminating Paradoxical and Psychophysiological Insomnia Based on Structural and Functional Brain Images: A Preliminary Machine Learning Study.

Afshani M, Mahmoudi-Aznaveh A, Noori K, Rostampour M, Zarei M, Spiegelhalder K Brain Sci. 2023; 13(4).

PMID: 37190637 PMC: 10136511. DOI: 10.3390/brainsci13040672.

References

Qiu M, Zhang H, Mellor D, Shi J, Wu C, Huang Y . Aberrant Neural Activity in Patients With Bipolar Depressive Disorder Distinguishing to the Unipolar Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2018; 9:238. PMC: 5996277. DOI: 10.3389/fpsyt.2018.00238. View

Skatun K, Kaufmann T, Tonnesen S, Biele G, Melle I, Agartz I . Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders. J Psychiatry Neurosci. 2016; 41(5):331-41. PMC: 5008922. DOI: 10.1503/jpn.150159. View

Geng X, Xu J, Liu B, Shi Y . Multivariate Classification of Major Depressive Disorder Using the Effective Connectivity and Functional Connectivity. Front Neurosci. 2018; 12:38. PMC: 5825897. DOI: 10.3389/fnins.2018.00038. View

Wang H, Zhang B, Zeng B, Tang Y, Zhang T, Zhao S . Association between catechol-O-methyltransferase genetic variation and functional connectivity in patients with first-episode schizophrenia. Schizophr Res. 2018; 199:214-220. DOI: 10.1016/j.schres.2018.04.023. View

Wang Y, Jiang Y, Su W, Xu L, Wei Y, Tang Y . Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study. Neuropsychiatr Dis Treat. 2021; 17:1505-1516. PMC: 8166279. DOI: 10.2147/NDT.S305117. View

Martino M, Magioncalda P, Huang Z, Conio B, Piaggio N, Duncan N . Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania. Proc Natl Acad Sci U S A. 2016; 113(17):4824-9. PMC: 4855585. DOI: 10.1073/pnas.1517558113. View

Zuo X, Ehmke R, Mennes M, Imperati D, Castellanos F, Sporns O . Network centrality in the human functional connectome. Cereb Cortex. 2011; 22(8):1862-75. DOI: 10.1093/cercor/bhr269. View

Hummer T, Hulvershorn L, Karne H, Gunn A, Wang Y, Anand A . Emotional response inhibition in bipolar disorder: a functional magnetic resonance imaging study of trait- and state-related abnormalities. Biol Psychiatry. 2012; 73(2):136-43. PMC: 5821068. DOI: 10.1016/j.biopsych.2012.06.036. View

Yang J, OuYang X, Tao H, Pu W, Fan Z, Zeng C . Connectomic signatures of working memory deficits in depression, mania, and euthymic states of bipolar disorder. J Affect Disord. 2020; 274:190-198. DOI: 10.1016/j.jad.2020.05.058. View

10.

Deng W, Zhang B, Zou W, Zhang X, Cheng X, Guan L . Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder. Front Psychiatry. 2019; 10:140. PMC: 6435527. DOI: 10.3389/fpsyt.2019.00140. View

11.

Marusak H, Calhoun V, Brown S, Crespo L, Sala-Hamrick K, Gotlib I . Dynamic functional connectivity of neurocognitive networks in children. Hum Brain Mapp. 2016; 38(1):97-108. PMC: 5796541. DOI: 10.1002/hbm.23346. View

12.

Hamilton M . The assessment of anxiety states by rating. Br J Med Psychol. 1959; 32(1):50-5. DOI: 10.1111/j.2044-8341.1959.tb00467.x. View

13.

Serafini G, Pompili M, Borgwardt S, Houenou J, Geoffroy P, Jardri R . Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents. Eur Child Adolesc Psychiatry. 2014; 23(11):1023-41. DOI: 10.1007/s00787-014-0614-z. View

14.

Bandettini P, Jesmanowicz A, Van Kylen J, Birn R, Hyde J . Functional MRI of brain activation induced by scanner acoustic noise. Magn Reson Med. 1998; 39(3):410-6. DOI: 10.1002/mrm.1910390311. View

15.

Harrison P, Geddes J, Tunbridge E . The Emerging Neurobiology of Bipolar Disorder. Focus (Am Psychiatr Publ). 2020; 17(3):284-293. PMC: 6996057. DOI: 10.1176/appi.focus.17309. View

16.

Zhong S, Chen G, Zhao L, Jia Y, Chen F, Qi Z . Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression. Neuroendocrinology. 2019; 108(3):232-243. DOI: 10.1159/000497182. View

17.

Yan C, Wang X, Zuo X, Zang Y . DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging. Neuroinformatics. 2016; 14(3):339-51. DOI: 10.1007/s12021-016-9299-4. View

18.

Faghiri A, Stephen J, Wang Y, Wilson T, Calhoun V . Changing brain connectivity dynamics: From early childhood to adulthood. Hum Brain Mapp. 2017; 39(3):1108-1117. PMC: 5807176. DOI: 10.1002/hbm.23896. View

19.

Maffei C, Fossati A, Agostoni I, Barraco A, Bagnato M, Deborah D . Interrater reliability and internal consistency of the structured clinical interview for DSM-IV axis II personality disorders (SCID-II), version 2.0. J Pers Disord. 1997; 11(3):279-84. DOI: 10.1521/pedi.1997.11.3.279. View

20.

Zhang Z, Bo Q, Li F, Zhao L, Wang Y, Liu R . Increased ALFF and functional connectivity of the right striatum in bipolar disorder patients. Prog Neuropsychopharmacol Biol Psychiatry. 2020; 111:110140. DOI: 10.1016/j.pnpbp.2020.110140. View