A Sustainable Approach for the Removal Methods and Analytical Determination Methods of Antiviral Drugs from Water/wastewater: A Review

Overview

Journal J Water Process Eng

Date 2022 Aug 15

PMID 35966450

Authors

Bahriye Eryildiz

Bahar Yavuzturk Gul

Ismail Koyuncu

Affiliations

Soon will be listed here.

Abstract

In the last years, antiviral drugs especially used for the treatment of COVID-19 have been considered emerging contaminants because of their continuous occurrence and persistence in water/wastewater even at low concentrations. Furthermore, as compared to antiviral drugs, their metabolites and transformation products of these pharmaceuticals are more persistent in the environment. They have been found in environmental matrices all over the world, demonstrating that conventional treatment technologies are unsuccessful for removing them from water/wastewater. Several approaches for degrading/removing antiviral drugs have been studied to avoid this contamination. In this study, the present level of knowledge on the input sources, occurrence, determination methods and, especially, the degradation and removal methods of antiviral drugs are discussed in water/wastewater. Different removal methods, such as conventional treatment methods (i.e. activated sludge), advanced oxidation processes (AOPs), adsorption, membrane processes, and combined processes, were evaluated. In addition, the antiviral drugs and these metabolites, as well as the transformation products created as a result of treatment, were examined. Future perspectives for removing antiviral drugs, their metabolites, and transformation products were also considered.

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References

OBrien J . Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1989; 37(3):233-309. DOI: 10.2165/00003495-198937030-00002. View

Ghosh G, Nakada N, Yamashita N, Tanaka H . Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants. Chemosphere. 2010; 81(1):13-7. DOI: 10.1016/j.chemosphere.2010.07.023. View

Lickfett T, Clark E, Gehring T, Alm E . Detection of Influenza A viruses at migratory bird stopover sites in Michigan, USA. Infect Ecol Epidemiol. 2018; 8(1):1474709. PMC: 5965024. DOI: 10.1080/20008686.2018.1474709. View

Hsu P, Chiu D, Wu K, Lee P, Jan J, Cheng Y . Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses. Eur J Med Chem. 2018; 154:314-323. DOI: 10.1016/j.ejmech.2018.05.030. View

Abafe O, Spath J, Fick J, Jansson S, Buckley C, Stark A . LC-MS/MS determination of antiretroviral drugs in influents and effluents from wastewater treatment plants in KwaZulu-Natal, South Africa. Chemosphere. 2018; 200:660-670. DOI: 10.1016/j.chemosphere.2018.02.105. View

Madelain V, Duthey A, Mentre F, Jacquot F, Solas C, Lacarelle B . Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates. Antiviral Res. 2020; 177:104758. DOI: 10.1016/j.antiviral.2020.104758. View

Radjenovic J, Petrovic M, Barcelo D . Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Anal Bioanal Chem. 2006; 387(4):1365-77. PMC: 1805043. DOI: 10.1007/s00216-006-0883-6. View

Brisebois E, Veillette M, Dion-Dupont V, Lavoie J, Corbeil J, Culley A . Human viral pathogens are pervasive in wastewater treatment center aerosols. J Environ Sci (China). 2018; 67:45-53. PMC: 7128102. DOI: 10.1016/j.jes.2017.07.015. View

Baskar A, Bolan N, Hoang S, Sooriyakumar P, Kumar M, Singh L . Recovery, regeneration and sustainable management of spent adsorbents from wastewater treatment streams: A review. Sci Total Environ. 2022; 822:153555. DOI: 10.1016/j.scitotenv.2022.153555. View

10.

Giokas D, Vlessidis A . Application of a novel chemometric approach to the determination of aqueous photolysis rates of organic compounds in natural waters. Talanta. 2008; 71(1):288-95. DOI: 10.1016/j.talanta.2006.03.060. View

11.

Vegivinti C, Pederson J, Saravu K, Gupta N, Barrett A, Davis A . Remdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. Ann Med Surg (Lond). 2021; 62:43-48. PMC: 7806502. DOI: 10.1016/j.amsu.2020.12.051. View

12.

Mestankova H, Schirmer K, Escher B, von Gunten U, Canonica S . Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes. Environ Pollut. 2012; 161:30-5. DOI: 10.1016/j.envpol.2011.09.018. View

13.

Wu F, Zhang J, Xiao A, Gu X, Lee W, Armas F . SARS-CoV-2 Titers in Wastewater Are Higher than Expected from Clinically Confirmed Cases. mSystems. 2020; 5(4). PMC: 7566278. DOI: 10.1128/mSystems.00614-20. View

14.

Shin J, Kwak J, Lee Y, Kim S, Choi M, Bae S . Competitive adsorption of pharmaceuticals in lake water and wastewater effluent by pristine and NaOH-activated biochars from spent coffee wastes: Contribution of hydrophobic and π-π interactions. Environ Pollut. 2020; 270:116244. DOI: 10.1016/j.envpol.2020.116244. View

15.

Kiyanmehr K, Moussavi G, Mohammadi S, Naddafi K, Giannakis S . The efficacy of the VUV/O process run in a continuous-flow fluidized bed reactor for simultaneous elimination of favipiravir and bacteria in aqueous matrices. Chemosphere. 2022; 304:135307. DOI: 10.1016/j.chemosphere.2022.135307. View

16.

Suttapanit K, Boriboon J, Sanguanwit P . Risk factors for non-invasive ventilation failure in influenza infection with acute respiratory failure in emergency department. Am J Emerg Med. 2020; 45:368-373. DOI: 10.1016/j.ajem.2020.08.094. View

17.

Papageorgiou M, Zioris I, Danis T, Bikiaris D, Lambropoulou D . Comprehensive investigation of a wide range of pharmaceuticals and personal care products in urban and hospital wastewaters in Greece. Sci Total Environ. 2019; 694:133565. DOI: 10.1016/j.scitotenv.2019.07.371. View

18.

Celebioglu A, Uyar T . Electrospun formulation of acyclovir/cyclodextrin nanofibers for fast-dissolving antiviral drug delivery. Mater Sci Eng C Mater Biol Appl. 2020; 118:111514. DOI: 10.1016/j.msec.2020.111514. View

19.

Gonzalez-Gil L, Krah D, Ghattas A, Carballa M, Wick A, Helmholz L . Biotransformation of organic micropollutants by anaerobic sludge enzymes. Water Res. 2019; 152:202-214. DOI: 10.1016/j.watres.2018.12.064. View

20.

Jang Y, Kim H, Ham S, Park J, Park H . Investigation of critical sludge characteristics for membrane fouling in a submerged membrane bioreactor: Role of soluble microbial products and extracted extracellular polymeric substances. Chemosphere. 2021; 271:129879. DOI: 10.1016/j.chemosphere.2021.129879. View