Evaluation of Applicability of Novel Markers of Metabolic Syndrome in Adult Men

Overview

Journal Am J Mens Health

Specialties Health Services
Public Health

Date 2022 Aug 13

PMID 35962582

Authors

Ryszard Tomasiuk

Affiliations

Soon will be listed here.

Abstract

There is a continuous worldwide increase in incidences of metabolic syndrome (MetS) reaching about a quarter of the world's population. Thus, studies that allow for a robust diagnosis of MetS are of paramount importance from an economic and medical point of view. This study was carried out in a group of men diagnosed with MetS using consensus definition criteria that included the definitions of the International Diabetes Foundation and Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. The control group consisted of men for whom the parameters that define the MetS were in the norm. This study analyzed statistical differences between MetS and healthy men and the correlations between the set of 14 potential markers of MetS, that is, between body mass index, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein, triglycerides, cortisol, adiponectin, monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), adipsin, leptin, resistin, and plasminogen activator inhibitor-1 (PAI)-1. This report revealed a significant difference between MetS and healthy men in most of the parameters studied. Furthermore, a strong positive correlation between cortisol levels and body mass index was demonstrated. Furthermore, MCP-1 levels in men with MetS were significantly higher than their levels in healthy men. Finally, a strong positive correlation was also observed between adiponectin and adipsin in Mets men. Thus, this study reveals the potential usefulness of adiponectin, MCP-1, adipsin, leptin, resistin, and PAI-1 as markers of MetS in adult men.

References

Al-Hamodi Z, Ismail I, Saif-Ali R, Ahmed K, Muniandy S . Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects. Cardiovasc Diabetol. 2011; 10:23. PMC: 3064636. DOI: 10.1186/1475-2840-10-23. View

Rabkin S, Langer A, Ur E, Calciu C, Leiter L . Inflammatory biomarkers CRP, MCP-1, serum amyloid alpha and interleukin-18 in patients with HTN and dyslipidemia: impact of diabetes mellitus on metabolic syndrome and the effect of statin therapy. Hypertens Res. 2013; 36(6):550-8. DOI: 10.1038/hr.2012.214. View

Jamaluddin M, Weakley S, Yao Q, Chen C . Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2011; 165(3):622-32. PMC: 3315035. DOI: 10.1111/j.1476-5381.2011.01369.x. View

Lachin J . Introduction to sample size determination and power analysis for clinical trials. Control Clin Trials. 1981; 2(2):93-113. DOI: 10.1016/0197-2456(81)90001-5. View

Tafere G, Wondafrash D, Zewdie K, Assefa B, Ayza M . Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020; 13:1855-1861. PMC: 7264027. DOI: 10.2147/DMSO.S253967. View

Valkovic T, Babarovic E, Lucin K, Stifter S, Aralica M, Seili-Bekafigo I . Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. Biomed Res Int. 2016; 2016:7870590. PMC: 4748063. DOI: 10.1155/2016/7870590. View

Lin K, Chiou J, Kuo H, Tan J, Ko S, Lee M . Associations Between Unhealthy Lifestyle Behaviors and Metabolic Syndrome by Gender in Young Adults. Biol Res Nurs. 2018; 21(2):173-181. DOI: 10.1177/1099800418816175. View

Ghadge A, Khaire A . Leptin as a predictive marker for metabolic syndrome. Cytokine. 2019; 121:154735. DOI: 10.1016/j.cyto.2019.154735. View

Malo E, Ukkola O, Jokela M, Moilanen L, Kahonen M, Nieminen M . Resistin is an indicator of the metabolic syndrome according to five different definitions in the Finnish Health 2000 survey. Metab Syndr Relat Disord. 2011; 9(3):203-10. DOI: 10.1089/met.2010.0106. View

10.

Rutter M, Meigs J, Sullivan L, DAgostino Sr R, Wilson P . C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study. Circulation. 2004; 110(4):380-5. DOI: 10.1161/01.CIR.0000136581.59584.0E. View

11.

Devaraj S, Xu D, Jialal I . C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis. Circulation. 2003; 107(3):398-404. DOI: 10.1161/01.cir.0000052617.91920.fd. View

12.

Saklayen M . The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018; 20(2):12. PMC: 5866840. DOI: 10.1007/s11906-018-0812-z. View

13.

Suliga E, Koziel D, Ciesla E, Gluszek S . Association between dietary patterns and metabolic syndrome in individuals with normal weight: a cross-sectional study. Nutr J. 2015; 14:55. PMC: 4455325. DOI: 10.1186/s12937-015-0045-9. View

14.

Kassi E, Pervanidou P, Kaltsas G, Chrousos G . Metabolic syndrome: definitions and controversies. BMC Med. 2011; 9:48. PMC: 3115896. DOI: 10.1186/1741-7015-9-48. View

15.

Ko K, Kim E, Baek U, Gang Z, Kang S . The relationship between physical activity levels and metabolic syndrome in male white-collar workers. J Phys Ther Sci. 2016; 28(11):3041-3046. PMC: 5140796. DOI: 10.1589/jpts.28.3041. View

16.

Shen W, Punyanitya M, Chen J, Gallagher D, Albu J, Pi-Sunyer X . Waist circumference correlates with metabolic syndrome indicators better than percentage fat. Obesity (Silver Spring). 2006; 14(4):727-36. PMC: 1894647. DOI: 10.1038/oby.2006.83. View

17.

Zhou Q, Ge Q, Ding Y, Qu H, Wei H, Wu R . Relationship between serum adipsin and the first phase of glucose-stimulated insulin secretion in individuals with different glucose tolerance. J Diabetes Investig. 2018; 9(5):1128-1134. PMC: 6123022. DOI: 10.1111/jdi.12819. View

18.

Cornier M, Dabelea D, Hernandez T, Lindstrom R, Steig A, Stob N . The metabolic syndrome. Endocr Rev. 2008; 29(7):777-822. PMC: 5393149. DOI: 10.1210/er.2008-0024. View

19.

Grundy S, Brewer Jr H, Cleeman J, Smith Jr S, Lenfant C . Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol. 2004; 24(2):e13-8. DOI: 10.1161/01.ATV.0000111245.75752.C6. View

20.

Nuttall F . Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutr Today. 2016; 50(3):117-128. PMC: 4890841. DOI: 10.1097/NT.0000000000000092. View