Matrix Metalloproteinase-9-1562 C/T Promoter Gene Polymorphism in Chronic Periodontitis: A Cross-sectional Observational Study

Overview

Journal J Indian Soc Periodontol

Date 2022 Aug 12

PMID 35959301

Authors

Puja Sarkar

Thamil Selvan Muthuraj

Prasanta Bandyopadhyay

Papita Ghosh

Affiliations

Soon will be listed here.

Abstract

Background: Matrix metalloproteinases (MMPs) are a major group of enzymes, released in inflamed periodontal tissues in large quantities, resulting in connective tissue matrix breakdown. One of the most predominant MMPs is MMP-9. Association between chronic periodontitis (CP) and MMP-9 gene polymorphism (GP) in some ethnic populations has been already established. The aim of the current study was to assess the association of single-nucleotide polymorphism in the promoter region of MMP-9 gene with CP in Kolkata population, if any.

Materials And Methods: Forty eligible individuals were recruited for the study and grouped as A and B: Group A (twenty periodontally healthy individuals) and Group B (twenty CP patients). Venous blood samples collected from all the forty individuals were used to isolate the genomic DNA. GP for MMP-9 gene was detected using polymerase chain reaction and sequencing method. The data obtained were then analyzed statistically.

Results: A significantly different genotypic and allelic variation was observed in the control and test groups, with C/T genotype and T allele present in only CP group.

Conclusion: Within the limitations of this study, we can conclude that there was no significant association between patients with periodontitis and MMP-9-1562 C/T promoter GP.

Citing Articles

Association of matrix metalloproteinases (MMPs) gene polymorphisms with periodontitis: a systematic review.

Pandey R, Gupta N, Jha T, Manzoor T GMS Hyg Infect Control. 2024; 19:Doc53.

PMID: 39553301 PMC: 11565592. DOI: 10.3205/dgkh000508.

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