Radionuclide I-labeled Albumin-indocyanine Green Nanoparticles for Synergistic Combined Radio-photothermal Therapy of Anaplastic Thyroid Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Aug 12

PMID 35957867

Authors

Xuemei Zhang

Ziyu Yan

Zhaowei Meng

Ning Li

Qiang Jia

Yiming Shen

Yanhui Ji

Affiliations

Soon will be listed here.

Abstract

Objectives: Anaplastic thyroid cancer (ATC) cells cannot retain the radionuclide iodine 131 (I) for treatment due to the inability to uptake iodine. This study investigated the feasibility of combining radionuclides with photothermal agents in the diagnosis and treatment of ATC.

Methods: I was labeled on human serum albumin (HSA) by the standard chloramine T method. I-HSA and indocyanine green (ICG) were non-covalently bound by a simple stirring to obtain I-HSA-ICG nanoparticles. Characterizations were performed . The cytotoxicity and imaging ability were investigated by cell/ experiments. The radio-photothermal therapy efficacy of the nanoparticles was evaluated at the cellular and levels.

Results: The synthesized nanoparticles had a suitable size (25-45 nm) and objective biosafety. Under the irradiation of near-IR light, the photothermal conversion efficiency of the nanoparticles could reach 24.25%. fluorescence imaging and single-photon emission CT (SPECT)/CT imaging in small animals confirmed that I-HSA-ICG/I-HSA-ICG nanoparticles could stay in tumor tissues for 4-6 days. Compared with other control groups, I-HSA-ICG nanoparticles had the most significant ablation effect on tumor cells under the irradiation of an 808-nm laser.

Conclusions: In summary, I-HSA-ICG nanoparticles could successfully perform dual-modality imaging and treatment of ATC, which provides a new direction for the future treatment of iodine-refractory thyroid cancer.

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