Endometriosis and Irritable Bowel Syndrome: A Systematic Review and Meta-analyses

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2022 Aug 12

PMID 35957857

Authors

Michelle Y Nabi

Samal Nauhria

Morgan Reel

Simon Londono

Anisha Vasireddi

Mina Elmiry

Prakash V A K Ramdass

Affiliations

Soon will be listed here.

Abstract

Objective: To estimate the pooled odds ratio of endometriosis and irritable bowel syndrome, and to estimate the pooled prevalence of irritable bowel syndrome in patients with endometriosis.

Data Sources: Using Cochrane Library, MEDLINE, Science Direct, ClinicalTrials.gov, Web of Science, and CINAHL, we conducted a systematic literature search through October 2021, using the key terms "endometriosis" and "irritable bowel syndrome." Articles had to be published in English or Spanish. No restriction on geographical location was applied.

Methods Of Study Selection: The following eligibility criteria were applied: full-text original articles; human studies; studies that investigated the association between endometriosis and irritable bowel syndrome. Two investigators screened and reviewed the studies. A total of 1,776 studies were identified in 6 separate databases. After screening and applying the eligibility criteria, a total of 17 studies were included for analyses. The meta-analysis of association between endometriosis and irritable bowel syndrome included 11 studies, and the meta-analysis on the prevalence of irritable bowel syndrome in endometriosis included 6 studies.

Tabulation Integration And Results: Overall 96,119 subjects were included in the main meta-analysis (11 studies) for endometriosis and irritable bowel syndrome, with 18,887 endometriosis patients and 77,171 controls. The odds of irritable bowel syndrome were approximately 3 times higher among patients with endometriosis compared with healthy controls (odds ratio 2.97; 95% confidence interval, 2.17 - 4.06). Similar results were obtained after subgroup analyses by endometriosis diagnosis, irritable bowel syndrome diagnostic criteria, and Newcastle-Ottawa Scale scores. Six studies reported prevalence rates of irritable bowel syndrome in women with endometriosis, ranging from 10.6 to 52%. The pooled prevalence of irritable bowel syndrome in women with endometriosis was 23.4% (95% confidence interval, 9.7 - 37.2).

Conclusion: Patients with endometriosis have an approximately threefold increased risk of developing irritable bowel syndrome. Development and recent update of Rome criteria has evolved the diagnosis of IBS, potential bias should still be considered as there are no specific tests available for diagnosis.

Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/displa y_record.php?ID=CRD42018080611], identifier [CRD42018080611].

Citing Articles

Prevalence of irritable bowel syndrome in endometriosis patients: A cross-sectional study.

Aldardier N, Eissa G, Shaheen A, Sanedi A, Alghamdi T, Habadi R J Family Med Prim Care. 2024; 13(11):4931-4936.

PMID: 39722942 PMC: 11668458. DOI: 10.4103/jfmpc.jfmpc_509_24.

Implication of the enteric glia in the IBS-like colonic inflammation associated with endometriosis.

Rivera-Arce L, Cruz M, Rodriguez-Cintron U, Torres-Pirela J, Appleyard C BMC Womens Health. 2024; 24(1):647.

PMID: 39707348 PMC: 11662455. DOI: 10.1186/s12905-024-03480-7.

Dietary and Nutritional Interventions for the Management of Endometriosis.

Abulughod N, Valakas S, El-Assaad F Nutrients. 2024; 16(23).

PMID: 39683382 PMC: 11643425. DOI: 10.3390/nu16233988.

Holistic approaches to living well with endometriosis.

Desai J, Strong S, Ball E F1000Res. 2024; 13():359.

PMID: 39649833 PMC: 11621616. DOI: 10.12688/f1000research.142586.2.

Review of the Patient Burden and Therapeutic Landscape of Irritable Bowel Syndrome with Constipation in the United States.

Sendzischew Shane M, Ruddy J, Cline M, Rosenbaum D, Edelstein S, Moshiree B Clin Exp Gastroenterol. 2024; 17:227-253.

PMID: 39114809 PMC: 11303673. DOI: 10.2147/CEG.S464375.

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