The Dual Roles of Nano Zero-Valent Iron and Zinc Oxide in Antibiotics Resistance Genes (ARGs) Spread in Sediment

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Aug 12

PMID 35954758

Authors

Ling Luo

Dahang Deng

Xin Zhao

Hairong Hu

Xinyi Li

Jidong Gu

Yan He

Gang Yang

Ouping Deng

Yinlong Xiao

Affiliations

Soon will be listed here.

Abstract

Nanoparticles (NPs) are widely used and ubiquitous in the environment, but the consequences of their release into the environment on antibiotics resistance genes (ARGs), microbial abundance, and community, are largely unknown. Therefore, this study examined the effect of nano zero-valent iron (nZVI) and zinc oxide (nZnO) on tetracycline resistance genes (tet-ARGs) and class 1 integron () in sediment under laboratory incubation. The coexistence of NPs and tetracycline (TC) on tet-ARGs/ was also investigated. It was found that nZVI and nZnO promoted tet-ARGs/ abundance in sediment without TC but reduced the inducing effect of TC on tet-ARGs/ in sediment overlaid with TC solution. Without TC, nZVI, , and the bacterial community could directly promote tet-ARGs spread in nZVI sediment, while and bacterial abundance were the most directly important reasons for tet-ARGs spread in nZnO sediment. With TC, nZVI and bacterial community could reduce tet-ARGs abundance in nZVI sediment, while nZnO and bacterial community could directly promote tet-ARGs in nZnO sediment. Finally, these findings provided valuable information for understanding the role of NPs in promoting and reducing ARGs in the environment.

References

Fajardo C, Ortiz L, Rodriguez-Membibre M, Nande M, Lobo M, Martin M . Assessing the impact of zero-valent iron (ZVI) nanotechnology on soil microbial structure and functionality: a molecular approach. Chemosphere. 2011; 86(8):802-8. DOI: 10.1016/j.chemosphere.2011.11.041. View

Zhang S, Lu J, Wang Y, Verstraete W, Yuan Z, Guo J . Insights of metallic nanoparticles and ions in accelerating the bacterial uptake of antibiotic resistance genes. J Hazard Mater. 2021; 421:126728. DOI: 10.1016/j.jhazmat.2021.126728. View

Song L, Wang C, Jiang G, Ma J, Li Y, Chen H . Bioaerosol is an important transmission route of antibiotic resistance genes in pig farms. Environ Int. 2021; 154:106559. DOI: 10.1016/j.envint.2021.106559. View

Osei Sekyere J . Current State of Resistance to Antibiotics of Last-Resort in South Africa: A Review from a Public Health Perspective. Front Public Health. 2016; 4:209. PMC: 5042966. DOI: 10.3389/fpubh.2016.00209. View

Aydin S, Aydin M, Beduk F, Ulvi A . Removal of antibiotics from aqueous solution by using magnetic FeO/red mud-nanoparticles. Sci Total Environ. 2019; 670:539-546. DOI: 10.1016/j.scitotenv.2019.03.205. View

Qiu Z, Yu Y, Chen Z, Jin M, Yang D, Zhao Z . Nanoalumina promotes the horizontal transfer of multiresistance genes mediated by plasmids across genera. Proc Natl Acad Sci U S A. 2012; 109(13):4944-9. PMC: 3323979. DOI: 10.1073/pnas.1107254109. View

Simonin M, Richaume A . Impact of engineered nanoparticles on the activity, abundance, and diversity of soil microbial communities: a review. Environ Sci Pollut Res Int. 2015; 22(18):13710-23. DOI: 10.1007/s11356-015-4171-x. View

Ren S, Boo C, Guo N, Wang S, Elimelech M, Wang Y . Photocatalytic Reactive Ultrafiltration Membrane for Removal of Antibiotic Resistant Bacteria and Antibiotic Resistance Genes from Wastewater Effluent. Environ Sci Technol. 2018; 52(15):8666-8673. DOI: 10.1021/acs.est.8b01888. View

Zhang Y, Geng J, Ma H, Ren H, Xu K, Ding L . Characterization of microbial community and antibiotic resistance genes in activated sludge under tetracycline and sulfamethoxazole selection pressure. Sci Total Environ. 2016; 571:479-86. DOI: 10.1016/j.scitotenv.2016.07.014. View

10.

Li N, Sheng G, Lu Y, Zeng R, Yu H . Removal of antibiotic resistance genes from wastewater treatment plant effluent by coagulation. Water Res. 2017; 111:204-212. DOI: 10.1016/j.watres.2017.01.010. View

11.

Jeevanandam J, Barhoum A, Chan Y, Dufresne A, Danquah M . Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein J Nanotechnol. 2018; 9:1050-1074. PMC: 5905289. DOI: 10.3762/bjnano.9.98. View

12.

Wang R, Chen M, Feng F, Zhang J, Sui Q, Tong J . Effects of chlortetracycline and copper on tetracyclines and copper resistance genes and microbial community during swine manure anaerobic digestion. Bioresour Technol. 2017; 238:57-69. DOI: 10.1016/j.biortech.2017.03.134. View

13.

Guo X, Zhu L, Zhong H, Li P, Zhang C, Wei D . Response of antibiotic and heavy metal resistance genes to tetracyclines and copper in substrate-free hydroponic microcosms with Myriophyllum aquaticum. J Hazard Mater. 2021; 413:125444. DOI: 10.1016/j.jhazmat.2021.125444. View

14.

Liu J, Gefen O, Ronin I, Bar-Meir M, Balaban N . Effect of tolerance on the evolution of antibiotic resistance under drug combinations. Science. 2020; 367(6474):200-204. DOI: 10.1126/science.aay3041. View

15.

Liu K, Sun M, Ye M, Chao H, Zhao Y, Xia B . Coexistence and association between heavy metals, tetracycline and corresponding resistance genes in vermicomposts originating from different substrates. Environ Pollut. 2018; 244:28-37. DOI: 10.1016/j.envpol.2018.10.022. View

16.

Luo L, Wang G, Wang Z, Ma J, He Y, He J . Optimization of Fenton process on removing antibiotic resistance genes from excess sludge by single-factor experiment and response surface methodology. Sci Total Environ. 2021; 788:147889. DOI: 10.1016/j.scitotenv.2021.147889. View

17.

Huang K, Xia H, Zhang Y, Li J, Cui G, Li F . Elimination of antibiotic resistance genes and human pathogenic bacteria by earthworms during vermicomposting of dewatered sludge by metagenomic analysis. Bioresour Technol. 2019; 297:122451. DOI: 10.1016/j.biortech.2019.122451. View

18.

Zhang X, Zhang T, Fang H . Antibiotic resistance genes in water environment. Appl Microbiol Biotechnol. 2009; 82(3):397-414. DOI: 10.1007/s00253-008-1829-z. View

19.

Chen Y, Li P, Huang Y, Yu K, Chen H, Cui K . Environmental media exert a bottleneck in driving the dynamics of antibiotic resistance genes in modern aquatic environment. Water Res. 2019; 162:127-138. DOI: 10.1016/j.watres.2019.06.047. View

20.

Feng G, Huang H, Chen Y . Effects of emerging pollutants on the occurrence and transfer of antibiotic resistance genes: A review. J Hazard Mater. 2021; 420:126602. DOI: 10.1016/j.jhazmat.2021.126602. View