Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Aug 12

PMID 35954497

Authors

Miguel Angel Gonzalez-Moles

Saman Warnakulasuriya

Maria Lopez-Ansio

Pablo Ramos-Garcia

Affiliations

Soon will be listed here.

Abstract

In 2000 and 2011, Hanahan and Weinberg published two papers in which they defined the characteristics that cells must fulfil in order to be considered neoplastic cells in all types of tumours that affect humans, which the authors called "hallmarks of cancer". These papers have represented a milestone in our understanding of the biology of many types of cancers and have made it possible to reach high levels of scientific evidence in relation to the prognostic impact that these hallmarks have on different tumour types. However, to date, there is no study that globally analyses evidence-based knowledge on the importance of these hallmarks in oral and oropharyngeal squamous cell carcinomas. For this reason, we set out to conduct this scoping review of systematic reviews with the aim of detecting evidence gaps in relation to the relevance of the cancer hallmarks proposed by Hanahan and Weinberg in oral and oropharyngeal cancer, and oral potentially malignant disorders, and to point out future lines of research in this field.

Citing Articles

Predictive Value of the Loss of pRb Expression in the Malignant Transformation Risk of Oral Potentially Malignant Disorders: A Systematic Review and Meta-Analysis.

Lopez-Ansio M, Ramos-Garcia P, Gonzalez-Moles M Cancers (Basel). 2025; 17(2).

PMID: 39858110 PMC: 11764026. DOI: 10.3390/cancers17020329.

Implications of p53 protein upregulation in oral lichen planus: a systematic review and meta-analysis.

Keim-Del Pino C, Ramos-Garcia P, Pimenta-Barros L, Gonzalez-Moles M Med Oral Patol Oral Cir Bucal. 2024; 29(6):e832-e842.

PMID: 39396145 PMC: 11584960. DOI: 10.4317/medoral.26808.

A Molecular Hypothesis on Malignant Transformation of Oral Lichen Planus: A Systematic Review and Meta-Analysis of Cancer Hallmarks Expression in This Oral Potentially Malignant Disorder.

Keim-Del Pino C, Ramos-Garcia P, Gonzalez-Moles M Cancers (Basel). 2024; 16(15).

PMID: 39123342 PMC: 11311016. DOI: 10.3390/cancers16152614.

Pathogenesis and Therapy of Oral Carcinogenesis.

Tarle M, Luksic I Int J Mol Sci. 2024; 25(12).

PMID: 38928050 PMC: 11203620. DOI: 10.3390/ijms25126343.

Effects of lactalbumin enzymatic hydrolysate on human squamous cell carcinoma cells-an study.

Arini A, Namangkalakul W, Limraksasin P, Osathanon T J Oral Biol Craniofac Res. 2024; 14(2):222-229.

PMID: 38495954 PMC: 10940804. DOI: 10.1016/j.jobcr.2024.02.011.

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