MicroRNA-Mediated Silencing Pathways in the Nervous System and Neurological Diseases

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Aug 12

PMID 35954216

Authors

Christian Barbato

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that play a prominent role in post-transcriptional gene regulation mechanisms in the brain tuning synaptic plasticity, memory formation, and cognitive functions in physiological and pathological conditions [...].

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References

Cogoni C, Ruberti F, Barbato C . MicroRNA landscape in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2015; 14(2):168-75. DOI: 10.2174/1871527314666150116123305. View

Kim S, Choi K, Park Y, McLean C, Park J, Lee J . Enhanced Expression of microRNA-1273g-3p Contributes to Alzheimer's Disease Pathogenesis by Regulating the Expression of Mitochondrial Genes. Cells. 2021; 10(10). PMC: 8534383. DOI: 10.3390/cells10102697. View

Contiliani D, Ribeiro Y, de Moraes V, Pereira T . MicroRNAs in Prion Diseases-From Molecular Mechanisms to Insights in Translational Medicine. Cells. 2021; 10(7). PMC: 8307047. DOI: 10.3390/cells10071620. View

Ghanbarian H, Aghamiri S, Eftekhary M, Wagner N, Wagner K . Small Activating RNAs: Towards the Development of New Therapeutic Agents and Clinical Treatments. Cells. 2021; 10(3). PMC: 8001863. DOI: 10.3390/cells10030591. View

Watson C, Begum G, Ashman E, Thorn D, Yakoub K, Al Hariri M . Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer's Disease Patients. Cells. 2022; 11(1). PMC: 8750061. DOI: 10.3390/cells11010163. View

Tasker R, Rowlands J, Ahmed Z, Di Pietro V . Co-Expression Network Analysis of Micro-RNAs and Proteins in the Alzheimer's Brain: A Systematic Review of Studies in the Last 10 Years. Cells. 2021; 10(12). PMC: 8699941. DOI: 10.3390/cells10123479. View

Han J, Mendell J . MicroRNA turnover: a tale of tailing, trimming, and targets. Trends Biochem Sci. 2022; 48(1):26-39. PMC: 9789169. DOI: 10.1016/j.tibs.2022.06.005. View

Li X, Wang X, Cheng Z, Zhu Q . AGO2 and its partners: a silencing complex, a chromatin modulator, and new features. Crit Rev Biochem Mol Biol. 2020; 55(1):33-53. DOI: 10.1080/10409238.2020.1738331. View

Thomas K, Zakharenko S . MicroRNAs in the Onset of Schizophrenia. Cells. 2021; 10(10). PMC: 8534348. DOI: 10.3390/cells10102679. View

10.

Blount G, Coursey L, Kocerha J . MicroRNA Networks in Cognition and Dementia. Cells. 2022; 11(12). PMC: 9221254. DOI: 10.3390/cells11121882. View

11.

Barbato C, Canu N, Zambrano N, Serafino A, Minopoli G, Ciotti M . Interaction of Tau with Fe65 links tau to APP. Neurobiol Dis. 2005; 18(2):399-408. DOI: 10.1016/j.nbd.2004.10.011. View

12.

Stojanovic T, Velarde Gamez D, Schuld G, Bormann D, Cabatic M, Uhrin P . Age-Dependent and Pathway-Specific Bimodal Action of Nicotine on Synaptic Plasticity in the Hippocampus of Mice Lacking the miR-132/212 Genes. Cells. 2022; 11(2). PMC: 8774101. DOI: 10.3390/cells11020261. View

13.

Florian I, Buruiana A, Timis T, Susman S, Florian I, Balasa A . An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain. Cells. 2021; 10(6). PMC: 8227573. DOI: 10.3390/cells10061373. View

14.

Canu N, Dus L, Barbato C, Ciotti M, Brancolini C, Rinaldi A . Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. J Neurosci. 1998; 18(18):7061-74. PMC: 6793249. View

15.

Barbato C, Frisone P, Braccini L, DAguanno S, Pieroni L, Ciotti M . Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons. Cells. 2022; 11(6). PMC: 8947033. DOI: 10.3390/cells11061052. View

16.

Bartel D . Metazoan MicroRNAs. Cell. 2018; 173(1):20-51. PMC: 6091663. DOI: 10.1016/j.cell.2018.03.006. View

17.

Bormann D, Stojanovic T, Cicvaric A, Schuld G, Cabatic M, Jan Ankersmit H . miRNA-132/212 Gene-Deletion Aggravates the Effect of Oxygen-Glucose Deprivation on Synaptic Functions in the Female Mouse Hippocampus. Cells. 2021; 10(7). PMC: 8306255. DOI: 10.3390/cells10071709. View

18.

Liu J, Zhou F, Guan Y, Meng F, Zhao Z, Su Q . The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis. Cells. 2022; 11(3). PMC: 8833997. DOI: 10.3390/cells11030572. View