A Comparative Analysis of Mucus Immunomodulatory Properties from Seven Marine Gastropods from the Mediterranean Sea

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Aug 12

PMID 35954185

Authors

Clementina Sansone

Cecilia Balestra

Luigi Pistelli

Angelo Del Mondo

David Osca

Christophe Brunet

Fabio Crocetta

Affiliations

Soon will be listed here.

Abstract

The treatment of inflammatory and immune-related diseases due to dysfunctioning of the immune system necessitates modulation of the immune response through immunomodulatory compounds. Marine environments are considered as a new frontier for health benefit product implementations. Marine biodiversity is still a low explored resource, despite it is expected to represent an important platform for chemical bioactive compounds. Within the phylum Mollusca, gastropods are known to synthetize mucus, the latter presenting relevant bioactive properties, e.g., related to immunomodulant molecules able to activate the innate and acquired immune system. This study proposes a bioprospecting of the immunomodulant activity of mucus isolated from seven common gastropod species from the Gulf of Naples (Mediterranean Sea). Results showed that not all mucus displayed a significant cytotoxic activity on the two human cancer cell lines A549 and A2058. On the other hand, the mucus from was strongly bioactive and was therefore thoroughly investigated at cellular, molecular, and protein levels on the human monocytes U937 line. It can conclusively induce monocyte differentiation in vitro and significantly stimulate natural immunity response.

Citing Articles

Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia.

Cutolo E, Campitiello R, Caferri R, Pagliuca V, Li J, Agathos S Mar Drugs. 2024; 22(7).

PMID: 39057413 PMC: 11278107. DOI: 10.3390/md22070304.

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