Nanobiotics Against Antimicrobial Resistance: Harnessing the Power of Nanoscale Materials and Technologies

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2022 Aug 11

PMID 35953826

Authors

Nayanika Chakraborty

Diksha Jha

Indrajit Roy

Pradeep Kumar

Shailendra Singh Gaurav

Kalisvar Marimuthu

Oon-Tek Ng

Rajamani Lakshminarayanan

Navin Kumar Verma

Hemant K Gautam

Affiliations

Soon will be listed here.

Abstract

Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of "post-antibiotic era". It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly due to the lack of new/next generation of antimicrobials. In this context, nanoscale materials with antimicrobial potential have a great promise to treat deadly pathogens. These functional materials are uniquely positioned to effectively interfere with the bacterial systems and augment biofilm penetration. Most importantly, the core substance, surface chemistry, shape, and size of nanomaterials define their efficacy while avoiding the development of AMR. Here, we review the mechanisms of AMR and emerging applications of nanoscale functional materials as an excellent substitute for conventional antibiotics. We discuss the potential, promises, challenges and prospects of nanobiotics to combat AMR.

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