Advances in the Biological Functions and Mechanisms of MiRNAs in the Development of Osteosarcoma

Overview

Journal Technol Cancer Res Treat

Specialties Biomedical Engineering
Oncology
Pharmacology

Date 2022 Aug 11

PMID 35950243

Authors

Zihe Dong

Zhipeng Liao

Yonglin He

Chengye Wu

Zixiang Meng

Baolong Qin

Ge Xu

Zeyang Li

Tianxin Sun

Yuyan Wen

Guangjie Li

Affiliations

Soon will be listed here.

Abstract

Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis.

Citing Articles

7-Geranyloxycoumarin modulated metastatic potential of osteosarcoma cells via interaction with MMPs and JAK1/2.

Hosseini F, Ahmadi A, Sarvi Z, Iranshahi M, Rassouli F Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 39954065 DOI: 10.1007/s00210-025-03847-z.

Gelatin-based biomaterials as a delivery strategy for osteosarcoma treatment.

Yang Q, Chen X, Liu J, He Y Front Pharmacol. 2025; 16:1537695.

PMID: 39936088 PMC: 11811086. DOI: 10.3389/fphar.2025.1537695.

Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma.

Wang L, Liu X, Lv H, Zhang H, Lin R, Xu S Biology (Basel). 2025; 14(1).

PMID: 39857292 PMC: 11759184. DOI: 10.3390/biology14010061.

The homeobox family gene signature predicts the prognosis of osteosarcoma and correlates with immune invasion.

Liu W, Xia K, Huang X, Wei Z, Wei Z, Guo W Sci Rep. 2025; 15(1):886.

PMID: 39762460 PMC: 11704140. DOI: 10.1038/s41598-024-84924-w.

MiRNA encoded PTEN's impact on clinical-pathological features and prognosis in osteosarcoma: A systematic review and meta-analysis.

Limijadi E, Novriansyah R, Respati D, Tjandra K PLoS One. 2024; 19(9):e0304543.

PMID: 39298504 PMC: 11412496. DOI: 10.1371/journal.pone.0304543.

References

Zeng Y, Cullen B . Sequence requirements for micro RNA processing and function in human cells. RNA. 2003; 9(1):112-23. PMC: 1370375. DOI: 10.1261/rna.2780503. View

Conrad M, Lorenz S, Proneth B . Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases. Trends Mol Med. 2020; 27(2):113-122. DOI: 10.1016/j.molmed.2020.08.010. View

Yang J, Lai E . Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell. 2011; 43(6):892-903. PMC: 3176435. DOI: 10.1016/j.molcel.2011.07.024. View

Cheng J, Huang B, Duan J, Yi K, Zhuang Z . miR-4295 promotes cell proliferation, migration and invasion of osteosarcoma through targeting interferon regulatory factor 1. Oncol Lett. 2020; 20(5):260. PMC: 7517570. DOI: 10.3892/ol.2020.12123. View

Jin Z, El-Deiry W . Overview of cell death signaling pathways. Cancer Biol Ther. 2005; 4(2):139-63. DOI: 10.4161/cbt.4.2.1508. View

Macfarlane L, Murphy P . MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics. 2011; 11(7):537-61. PMC: 3048316. DOI: 10.2174/138920210793175895. View

Jung Y, Park J . Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex. Exp Mol Med. 2020; 52(2):183-191. PMC: 7062731. DOI: 10.1038/s12276-020-0380-6. View

Huang W, Chen Q, Dai J, Zhang Y, Yi Y, Wei X . miR-744-5p suppresses tumor proliferation and metastasis by targeting transforming growth factor-beta 1 (TGF-β1) in hepatocellular carcinoma (HCC). J Gastrointest Oncol. 2021; 12(4):1811-1822. PMC: 8421904. DOI: 10.21037/jgo-21-319. View

Song Y, Li D, Guan Y, Wang Y, Zheng J . miR-214 modulates cisplatin sensitivity of osteosarcoma cells through regulation of anaerobic glycolysis. Cell Mol Biol (Noisy-le-grand). 2017; 63(9):75-79. DOI: 10.14715/cmb/2017.63.9.14. View

10.

Tian W, Yuan X, Song Y, Zhai J, Wei H, Wang L . miR-218 inhibits glucose metabolism in non-small cell lung cancer via the NF-κB signaling pathway. Exp Ther Med. 2020; 21(2):106. PMC: 7739860. DOI: 10.3892/etm.2020.9538. View

11.

Lu S, Liao Q, Tang L . MiR-155 affects osteosarcoma cell proliferation and invasion through regulating NF-κB signaling pathway. Eur Rev Med Pharmacol Sci. 2018; 22(22):7633-7639. DOI: 10.26355/eurrev_201811_16380. View

12.

Dhital S, Deo P, Stuart I, Naderer T . Bacterial outer membrane vesicles and host cell death signaling. Trends Microbiol. 2021; 29(12):1106-1116. DOI: 10.1016/j.tim.2021.04.003. View

13.

Wang Y, Zheng Y, Chen Q, Dai Y, Li T . MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway. Arch Biochem Biophys. 2020; 704:108719. DOI: 10.1016/j.abb.2020.108719. View

14.

Li G, Li Y, Wang D . Overexpression of miR-329-3p sensitizes osteosarcoma cells to cisplatin through suppression of glucose metabolism by targeting LDHA. Cell Biol Int. 2020; 45(4):766-774. DOI: 10.1002/cbin.11476. View

15.

Lee Y, Jeon K, Lee J, Kim S, Kim V . MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 2002; 21(17):4663-70. PMC: 126204. DOI: 10.1093/emboj/cdf476. View

16.

Zhou L, Ma X, Yue J, Chen T, Wang X, Wang Z . The diagnostic effect of serum miR-139-5p as an indicator in osteosarcoma. Cancer Biomark. 2018; 23(4):561-567. DOI: 10.3233/CBM-181744. View

17.

Lu C, Peng K, Guo H, Ren X, Hu S, Cai Y . miR-18a-5p promotes cell invasion and migration of osteosarcoma by directly targeting IRF2. Oncol Lett. 2018; 16(3):3150-3156. PMC: 6096157. DOI: 10.3892/ol.2018.9032. View

18.

Hu S, Chang J, Ruan H, Zhi W, Wang X, Zhao F . Cantharidin inhibits osteosarcoma proliferation and metastasis by directly targeting miR-214-3p/DKK3 axis to inactivate β-catenin nuclear translocation and LEF1 translation. Int J Biol Sci. 2021; 17(10):2504-2522. PMC: 8315017. DOI: 10.7150/ijbs.51638. View

19.

Voorhoeve P, le Sage C, Schrier M, Gillis A, Stoop H, Nagel R . A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell. 2006; 124(6):1169-81. DOI: 10.1016/j.cell.2006.02.037. View

20.

Yu H, Song H, Liu L, Hu S, Liao Y, Li G . MiR-92a modulates proliferation, apoptosis, migration, and invasion of osteosarcoma cell lines by targeting Dickkopf-related protein 3. Biosci Rep. 2019; 39(4). PMC: 6487267. DOI: 10.1042/BSR20190410. View