» Articles » PMID: 35948133

A Brief History of Epigenetics

Overview
Journal Immunol Lett
Date 2022 Aug 10
PMID 35948133
Authors
Affiliations
Soon will be listed here.
Abstract

Over the past 70 years, the study of epigenetics has evolved from a research curiosity for outsiders to one of the most hyped biological concepts. While the pioneers of epigenetic research were met with disbelief when they described phenomena that did not follow the normal Mendelian laws of inheritance, the popular media today praises the modulation of epigenetics through behavioral changes as a cure for diseases. The concept that environmental influences can cause stable, heritable changes in gene expression has been embraced with such enthusiasm that the study of epigenetics has found its place in virtually every medical biology field. Because of the somewhat inflationary way in which the word epigenetics is used nowadays, it is all the more important to clarify definitions and terms before talking about epigenetic studies.

Citing Articles

The intersection of epigenetics and immune thrombocytopenia: new insights into disease mechanisms and treatments.

Zhou X, Shan N Mol Biol Rep. 2025; 52(1):257.

PMID: 39982580 DOI: 10.1007/s11033-025-10363-z.


DNA and RNA Methylation in Rheumatoid Arthritis-A Narrative Review.

Kielbowski K, Bakinowska E, Goracy-Rosik A, Figiel K, Judek R, Rosik J Epigenomes. 2025; 9(1.

PMID: 39846569 PMC: 11755448. DOI: 10.3390/epigenomes9010002.


The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review.

Letchumanan P, Das K Epigenetics Chromatin. 2025; 18(1):1.

PMID: 39754177 PMC: 11697457. DOI: 10.1186/s13072-024-00564-4.


The Future of Pharmacogenomics: Integrating Epigenetics, Nutrigenomics, and Beyond.

Shaman J J Pers Med. 2024; 14(12).

PMID: 39728034 PMC: 11677977. DOI: 10.3390/jpm14121121.


LINE-1 cfDNA Methylation as an Emerging Biomarker in Solid Cancers.

Gezer U, Ozgur E, Yoruker E, Polatoglou E, Holdenrieder S, Bronkhorst A Cancers (Basel). 2024; 16(22).

PMID: 39594682 PMC: 11592170. DOI: 10.3390/cancers16223725.