New Insights into the Epigenomic Landscape of Small-Cell Lung Cancer: A Game Changer?

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2022 Aug 10

PMID 35947642

Authors

Poonam Sarode

Soni Savai Pullamsetti

Rajkumar Savai

Affiliations

Soon will be listed here.

References

Vaharautio A, Taipale J . Cancer. Cancer by super-enhancer. Science. 2014; 346(6215):1291-2. DOI: 10.1126/science.aaa3247. View

Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H . Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004; 6(1):17-32. DOI: 10.1016/j.ccr.2004.06.010. View

Mancarella D, Plass C . Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation. Genome Med. 2021; 13(1):23. PMC: 7874645. DOI: 10.1186/s13073-021-00837-7. View

Siegel R, Miller K, Jemal A . Cancer statistics, 2019. CA Cancer J Clin. 2019; 69(1):7-34. DOI: 10.3322/caac.21551. View

Wooten D, Groves S, Tyson D, Liu Q, Lim J, Albert R . Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers. PLoS Comput Biol. 2019; 15(10):e1007343. PMC: 6860456. DOI: 10.1371/journal.pcbi.1007343. View

Peifer M, Fernandez-Cuesta L, Sos M, George J, Seidel D, Kasper L . Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet. 2012; 44(10):1104-10. PMC: 4915822. DOI: 10.1038/ng.2396. View

George J, Lim J, Jang S, Cun Y, Ozretic L, Kong G . Comprehensive genomic profiles of small cell lung cancer. Nature. 2015; 524(7563):47-53. PMC: 4861069. DOI: 10.1038/nature14664. View

Iwafuchi-Doi M, Zaret K . Pioneer transcription factors in cell reprogramming. Genes Dev. 2014; 28(24):2679-92. PMC: 4265672. DOI: 10.1101/gad.253443.114. View

Gay C, Stewart C, Park E, Diao L, Groves S, Heeke S . Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell. 2021; 39(3):346-360.e7. PMC: 8143037. DOI: 10.1016/j.ccell.2020.12.014. View

10.

Kong R, Patel A, Sato T, Jiang F, Yoo S, Bao L . Transcriptional Circuitry of NKX2-1 and SOX1 Defines an Unrecognized Lineage Subtype of Small-Cell Lung Cancer. Am J Respir Crit Care Med. 2022; 206(12):1480-1494. PMC: 9757094. DOI: 10.1164/rccm.202110-2358OC. View

11.

Rudin C, Poirier J, Byers L, Dive C, Dowlati A, George J . Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer. 2019; 19(5):289-297. PMC: 6538259. DOI: 10.1038/s41568-019-0133-9. View

12.

Zhao L, Lee V, Ng M, Yan H, Bijlsma M . Molecular subtyping of cancer: current status and moving toward clinical applications. Brief Bioinform. 2018; 20(2):572-584. DOI: 10.1093/bib/bby026. View

13.

Trynka G, Sandor C, Han B, Xu H, Stranger B, Liu X . Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet. 2012; 45(2):124-30. PMC: 3826950. DOI: 10.1038/ng.2504. View

14.

Moffitt R, Marayati R, Flate E, Volmar K, Loeza S, Hoadley K . Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet. 2015; 47(10):1168-78. PMC: 4912058. DOI: 10.1038/ng.3398. View

15.

Goldman J, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D . Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2020; 22(1):51-65. DOI: 10.1016/S1470-2045(20)30539-8. View

16.

Horn L, Mansfield A, Szczesna A, Havel L, Krzakowski M, Hochmair M . First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer. N Engl J Med. 2018; 379(23):2220-2229. DOI: 10.1056/NEJMoa1809064. View