Effect of Evodiamine on Collagen-Induced Platelet Activation and Thrombosis

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2022 Aug 8

PMID 35937403

Authors

Xiaona Yang

Min Leng

Lihong Yang

Yunzhu Peng

Jing Wang

Qian Wang

Kun Wu

Junhua Zou

Wen Wan

Longjun Li

Yujia Ye

Zhaohui Meng

Affiliations

Soon will be listed here.

Abstract

Evodia rutaecarpa has multiple pharmacological effects and is widely used in the prevention and treatment of migraine, diabetes, cardiovascular disease, cancer, and other chronic diseases; however, the pharmacological effects of its active compound evodiamine (Evo) have not been thoroughly investigated. The purpose of this study was to investigate the effects of Evo on antiplatelet activation and thrombosis. We discovered that Evo effectively inhibited collagen-induced platelet activation but had no effect on platelet aggregation caused by activators such as thrombin, ADP, and U46619. Second, we found that Evo effectively inhibited the release of platelet granules induced by collagen. Finally, evodiamine inhibits the transduction of the SFKs/Syk/Akt/PLC2 activation pathway in platelets. According to in vivo studies, Evo significantly prolonged the mesenteric thromboembolism induced by ferric chloride and had no discernible effect on the coagulation function of mice. In conclusion, the antiplatelet and thrombotic effects of Evo discovered in this study provide an experimental basis for the investigation of the pharmacological mechanisms of Evo and the development of antiplatelet drugs.

Citing Articles

Antithrombic effects of in a rat model of acute thrombosis: modulation of endothelial adhesion molecules and inflammatory factors.

Jo S, Park S, Lee J, Gwon Y, Kim J Food Sci Biotechnol. 2025; 34(1):269-276.

PMID: 39758728 PMC: 11695558. DOI: 10.1007/s10068-024-01625-w.

Retracted: Effect of Evodiamine on Collagen-Induced Platelet Activation and Thrombosis.

International B Biomed Res Int. 2024; 2024:9850671.

PMID: 38230096 PMC: 10791273. DOI: 10.1155/2024/9850671.

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