Modulation of Cardiometabolic Risk and CardioRenal Syndrome by Oral Vitamin D Supplementation in Black and White Southern Sahara Residents with Chronic Kidney Disease Stage 3: Focus on Racial and Ethnic Disparities

Overview

Journal Ren Fail

Publisher Informa Healthcare

Date 2022 Aug 5

PMID 35930297

Authors

Asma Bouazza

Amina Tahar

Samir AitAbderrhmane

Messaoud Saidani

Elhadj-Ahmed Koceir

Affiliations

Soon will be listed here.

Abstract

Objectives: Several studies have shown that cholecalciferol supplementation (25OHD-S) in chronic kidney disease (CKD) improves kidney injury by reducing fibrosis-related vascular calcification and declining apoptosis-linked nephron damage.

Methods: The oral 25OHD-S was evaluated in 60,000 IU/month/36 weeks in 2000 IU/d/24 weeks in CKD Stage 3 with serum 25OHD level < 20 ng/mL. The study was undertaken on 156 black subjects and 150 white subjects Southern Sahara (SS). All biomarkers of cardiometabolic (CMet) and cardiorenal (CRenal) syndrome, Renin-angiotensin-aldosterone system (RAAS) profile, secondary hyperparathyroidism (SHPT), N-terminal pro B-type natriuretic peptide (NT-proBNP), Troponin T (cTnT) and atherogenicity risk were assessed by biochemical methods. Estimate glomerular filtration rate (eGFR) by chronic CKD-EPI equation formula. Total serum vitamin D by liquid chromatography-tandem mass spectrometry (MS).

Results: Vitamin D deficiency alters in the same manner CMet, CRenal, and others biomarkers in both groups SS; however, these disorders are more acute in blacks compared to whites SS. Oral 25OHD-S a highlighted improvement of eGFR drop, SHPT decrease, decline proteinuria, and cardiac failure risk (NT-proBNP and cTnT) attenuation. Concomitantly, 25OHD-S normalizes , , and (RAAS) activity. Nevertheless, homocysteine and Lp (a) do not modulate by 25OHD-S.

Conclusions: The oral vitamin D3 supplementation, according the dose, and the treatment duration does not like in black-skinned people to white-skinned inhabitants, while the 02 groups are native to the same Saharan environment. It emerge that a high intermittent dose through an extensive supplementation (60,000 IU/36 weeks) was more effective in black subjects. At opposite, a lower dose during a short period supplementation is sufficient (2000 IU/24 weeks) in white subjects.

Citing Articles

Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies.

Zhao B, Hu X, Wang W, Zhou Y Acta Pharmacol Sin. 2025; .

PMID: 39910210 DOI: 10.1038/s41401-025-01476-z.

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