Design, Synthesis, and Antifungal Activity of Novel 1,2,4-Triazolo[4,3-]trifluoromethylpyrimidine Derivatives Bearing the Thioether Moiety

Overview

Journal Front Chem

Specialty Chemistry

Date 2022 Aug 5

PMID 35928214

Authors

Chunyi Liu

Qiang Fei

Nianjuan Pan

Wenneng Wu

Affiliations

Soon will be listed here.

Abstract

Crop disease caused by fungi seriously affected food security and economic development. Inspired by the utilization of fungicide containing 1,2,4-triazole and trifluoromethylpyrimidine, a novel series of 1,2,4-triazolo[4,3-]trifluoromethylpyrimidine derivatives bearing the thioether moiety were synthesized. Meanwhile, the antifungal activities of the title compounds were evaluated and most compounds exhibited obvious antifungal activities against cucumber , strawberry , tobacco , blueberry , , and Cav. Among the compounds, 4, 5h, 5o, and 5r showed significant antifungal activities against three of the four , which indicated the potential to become the leading structures or candidates for resistance to .

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