Modulation of Neural Co-firing to Enhance Network Transmission and Improve Motor Function After Stroke
Overview
Affiliations
Stroke is a leading cause of disability. While neurotechnology has shown promise for improving upper limb recovery after stroke, efficacy in clinical trials has been variable. Our central thesis is that to improve clinical translation, we need to develop a common neurophysiological framework for understanding how neurotechnology alters network activity. Our perspective discusses principles for how motor networks, both healthy and those recovering from stroke, subserve reach-to-grasp movements. We focus on neural processing at the resolution of single movements, the timescale at which neurotechnologies are applied, and discuss how this activity might drive long-term plasticity. We propose that future studies should focus on cross-area communication and bridging our understanding of timescales ranging from single trials within a session to across multiple sessions. We hope that this perspective establishes a combined path forward for preclinical and clinical research with the goal of more robust clinical translation of neurotechnology.
Activity-dependent transcriptional programs in memory regulate motor recovery after stroke.
Joy M, Carmichael S Commun Biol. 2024; 7(1):1048.
PMID: 39183218 PMC: 11345429. DOI: 10.1038/s42003-024-06723-3.
Editorial: Advanced neurotechnology in stroke rehabilitation.
Sun J, Li C Front Neurol. 2024; 15:1440752.
PMID: 38966087 PMC: 11222633. DOI: 10.3389/fneur.2024.1440752.
Cross-Frequency Coupling as a Biomarker for Early Stroke Recovery.
Mark J, Riddle J, Gangwani R, Huang B, Frohlich F, Cassidy J Neurorehabil Neural Repair. 2024; 38(7):506-517.
PMID: 38842027 PMC: 11179969. DOI: 10.1177/15459683241257523.
Simpson B, Rangwani R, Abbasi A, Chung J, Reed C, Gulati T Front Neurol. 2023; 14:1243575.
PMID: 38099067 PMC: 10719949. DOI: 10.3389/fneur.2023.1243575.
Emergence of task-related spatiotemporal population dynamics in transplanted neurons.
Ghuman H, Kim K, Barati S, Ganguly K Nat Commun. 2023; 14(1):7320.
PMID: 37951968 PMC: 10640594. DOI: 10.1038/s41467-023-43081-w.