Potential Roles of Gut Microbiota and Microbial Metabolites in Chronic Inflammatory Pain and the Mechanisms of Therapy Drugs

Overview

Journal Ther Adv Chronic Dis

Publisher Sage Publications

Date 2022 Aug 4

PMID 35924009

Authors

Jia-Shang Li

Shu-Lan Su

Zhuo Xu

Li-Hui Zhao

Ruo-Ying Fan

Jian-Ming Guo

Da-Wei Qian

Jin-Ao Duan

Affiliations

Soon will be listed here.

Abstract

Observational findings achieved that gut microbes mediate human metabolic health and disease risk. The types of intestinal microorganisms depend on the intake of food and drugs and are also related to their metabolic level and genetic factors. Recent studies have shown that chronic inflammatory pain is closely related to intestinal microbial homeostasis. Compared with the normal intestinal flora, the composition of intestinal flora in patients with chronic inflammatory pain had significant changes in , , , etc. At the same time, short-chain fatty acids and amino acids, the metabolites of intestinal microorganisms, can regulate neural signal molecules and signaling pathways, thus affecting the development trend of chronic inflammatory pain. Glucocorticoids and non-steroidal anti-inflammatory drugs in the treatment of chronic inflammatory pain, the main mechanism is to affect the secretion of inflammatory factors and the abundance of intestinal bacteria. This article reviews the relationship between intestinal microorganisms and their metabolites on chronic inflammatory pain and the possible mechanism.

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References

Ma Q, Li Y, Li P, Wang M, Wang J, Tang Z . Research progress in the relationship between type 2 diabetes mellitus and intestinal flora. Biomed Pharmacother. 2019; 117:109138. DOI: 10.1016/j.biopha.2019.109138. View

Shao B, Xu Z, Han B, Su D, Liu C . NLRP3 inflammasome and its inhibitors: a review. Front Pharmacol. 2015; 6:262. PMC: 4633676. DOI: 10.3389/fphar.2015.00262. View

Hua C, Geng Y, Chen Q, Niu L, Cai L, Tao S . Chronic dexamethasone exposure retards growth without altering the digestive tract microbiota composition in goats. BMC Microbiol. 2018; 18(1):112. PMC: 6131888. DOI: 10.1186/s12866-018-1253-1. View

Patterson E, Ryan P, Cryan J, Dinan T, Ross R, Fitzgerald G . Gut microbiota, obesity and diabetes. Postgrad Med J. 2016; 92(1087):286-300. DOI: 10.1136/postgradmedj-2015-133285. View

Pascart T, Richette P . Colchicine in Gout: An Update. Curr Pharm Des. 2018; 24(6):684-689. DOI: 10.2174/1381612824999180115103951. View

Chen Z, Zhijie C, Yuting Z, Shilin X, Qichun Z, Jinying O . Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Front Microbiol. 2020; 11:946. PMC: 7326116. DOI: 10.3389/fmicb.2020.00946. View

Sakurai M, Yamamoto Y, Kanayama N, Hasegawa M, Mouri A, Takemura M . Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder. Sci Rep. 2020; 10(1):1961. PMC: 7005270. DOI: 10.1038/s41598-020-58806-w. View

Iannitti T, McDermott M, Laurino C, Malagoli A, Palmieri B . Corticosteroid transdermal delivery significantly improves arthritis pain and functional disability. Drug Deliv Transl Res. 2016; 7(1):156-161. PMC: 5222900. DOI: 10.1007/s13346-016-0340-9. View

Santharam M, Ullah Khan F, Naveed M, Ali U, Ahsan M, Khongorzul P . Interventions to chronic prostatitis/Chronic pelvic pain syndrome treatment. Where are we standing and what's next?. Eur J Pharmacol. 2019; 857:172429. DOI: 10.1016/j.ejphar.2019.172429. View

10.

van der Woude D, van der Helm-van Mil A . Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2018; 32(2):174-187. DOI: 10.1016/j.berh.2018.10.005. View

11.

Shi Y, Li J, Yang P, Niu Z, Wei L, Chen L . Colchicine increases intestinal permeability, suppresses inflammatory responses, and alters gut microbiota in mice. Toxicol Lett. 2020; 334:66-77. DOI: 10.1016/j.toxlet.2020.09.018. View

12.

Dehlin M, Jacobsson L, Roddy E . Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020; 16(7):380-390. DOI: 10.1038/s41584-020-0441-1. View

13.

Shoskes D, Wang H, Polackwich A, Tucky B, Altemus J, Eng C . Analysis of Gut Microbiome Reveals Significant Differences between Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls. J Urol. 2016; 196(2):435-41. DOI: 10.1016/j.juro.2016.02.2959. View

14.

Vitkov L, Hannig M, Minnich B, Herrmann M . Periodontal sources of citrullinated antigens and TLR agonists related to RA. Autoimmunity. 2018; 51(6):304-309. DOI: 10.1080/08916934.2018.1527907. View

15.

Norling L, Perretti M . The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol. 2013; 13(3):476-81. DOI: 10.1016/j.coph.2013.02.003. View

16.

Colucci R, Pellegrini C, Fornai M, Tirotta E, Antonioli L, Renzulli C . Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention. Front Pharmacol. 2018; 9:1340. PMC: 6281992. DOI: 10.3389/fphar.2018.01340. View

17.

Biernat K, Pellock S, Bhatt A, Bivins M, Walton W, Tran B . Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases. Sci Rep. 2019; 9(1):825. PMC: 6351562. DOI: 10.1038/s41598-018-36069-w. View

18.

Johnson R, Nakagawa T, Jalal D, Sanchez-Lozada L, Kang D, Ritz E . Uric acid and chronic kidney disease: which is chasing which?. Nephrol Dial Transplant. 2013; 28(9):2221-8. PMC: 4318947. DOI: 10.1093/ndt/gft029. View

19.

Sun F, Zhang Y, Li Q . Therapeutic mechanisms of ibuprofen, prednisone and betamethasone in osteoarthritis. Mol Med Rep. 2016; 15(2):981-987. DOI: 10.3892/mmr.2016.6068. View

20.

Magistro G, Wagenlehner F, Grabe M, Weidner W, Stief C, Nickel J . Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Eur Urol. 2015; 69(2):286-97. DOI: 10.1016/j.eururo.2015.08.061. View