Au-doped MOFs Catalyzed Electrochemiluminescence Platform Coupled with Target-induced Self-enrichment for Detection of Synthetic Cannabinoid RCS-4

Overview

Journal Mikrochim Acta

Specialties Biotechnology
Chemistry

Date 2022 Aug 3

PMID 35922727

Authors

Qianying Cao

Ding Jiang

Fangmin Xu

Jing Wen

Wenchang Wang

Hiroshi Shiigi

Zhidong Chen

Affiliations

Soon will be listed here.

Abstract

A ternary composite material with Au, Co-based organic frameworks (ZIF-67) and perylene derivatives (PTCD-cys) has been synthesized for identification of synthetic cannabinoids. Through contact with Au-S, Au-ZIF-67 increased electrochemiluminescence (ECL) sensitivity and stability and efficiently catalyzed the ECL of PTCD-cys. Compared with the ECL response of PTCD-cys monomer, the ECL signal value of the composite material was significantly increased, and the onset potential of Au-ZIF-67/PTCD-cys favorably shifted more than that of PTCD-cys/GCE. When the target cannabinoid molecule RCS-4 appeared, Au-ZIF-67 captured and immobilized it on the sensor surface by adsorption to achieve target-induced self-enrichment of RCS-4. Under optimal conditions, the ECL sensor was found to be linearly related to the logarithm of the RCS-4 concentration ranging from 3.1 × 10 to 3.1 × 10 mol/L with a detection limit (LOD) of 6.0 × 10 mol/L (S/N = 3). The approach had the advantages of being simple to use, having a high sensitivity, a wide detection range, and good stability, making it a novel platform for RSC-4 detection in public health safety monitoring.

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