» Articles » PMID: 35919809

Empagliflozin in the Treatment of Heart Failure and Type 2 Diabetes Mellitus: Evidence from Several Large Clinical Trials

Overview
Journal Int J Med Sci
Specialty General Medicine
Date 2022 Aug 3
PMID 35919809
Authors
Affiliations
Soon will be listed here.
Abstract

Heart failure coexists with type 2 diabetes mellitus, which seriously affects the clinical treatment and prognosis. At present, the treatment for patients with established heart failure and type 2 diabetes mellitus is usually combined with two treatment strategies for heart failure and type 2 diabetes mellitus. Recently, increasing studies showed that empagliflozin, a sodium-glucose co-transporter-2 inhibitor, has a positive effect on the treatment of patients with established heart failure and type 2 diabetes mellitus. Here, we summarize the latest and current understanding of the management for patients with established heart failure and type 2 diabetes mellitus and further present contemporary treatment options, sodium-glucose co-transporter-2 inhibitor, for these particular populations.

Citing Articles

Cardiovascular Diseases: Therapeutic Potential of SGLT-2 Inhibitors.

Frak W, Hajdys J, Radzioch E, Szlagor M, Mlynarska E, Rysz J Biomedicines. 2023; 11(7).

PMID: 37509724 PMC: 10377079. DOI: 10.3390/biomedicines11072085.


Assessment of the Safety, Efficacy, and Benefit of Empagliflozin in Patients With Type 2 Diabetes Mellitus (T2DM) and Heart Failure With Reduced Ejection Fraction (HFrEF) at High Risk for Cardiovascular Events.

Towiargi R, Fetyani L, Aljahdali N, Alnofeie A, AlNoamy Y, Ghandorah R Cureus. 2023; 14(12):e33070.

PMID: 36721538 PMC: 9883530. DOI: 10.7759/cureus.33070.


Empagliflozin for Patients with Heart Failure and Type 2 Diabetes Mellitus: Clinical Evidence in Comparison with Other Sodium-Glucose Co-transporter-2 Inhibitors and Potential Mechanism.

Liang B, Li R, Zhang P, Gu N J Cardiovasc Transl Res. 2022; 16(2):327-340.

PMID: 35969357 DOI: 10.1007/s12265-022-10302-4.

References
1.
Butler J, Filippatos G, Siddiqi T, Brueckmann M, Bohm M, Chopra V . Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial. Circulation. 2021; 145(3):184-193. PMC: 8763045. DOI: 10.1161/CIRCULATIONAHA.121.057812. View

2.
Pasternak B, Ueda P, Eliasson B, Svensson A, Franzen S, Gudbjornsdottir S . Use of sodium glucose cotransporter 2 inhibitors and risk of major cardiovascular events and heart failure: Scandinavian register based cohort study. BMJ. 2019; 366:l4772. PMC: 6713906. DOI: 10.1136/bmj.l4772. View

3.
Packer M, Anker S, Butler J, Filippatos G, Pocock S, Carson P . Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020; 383(15):1413-1424. DOI: 10.1056/NEJMoa2022190. View

4.
Jankauskas S, Kansakar U, Varzideh F, Wilson S, Mone P, Lombardi A . Heart failure in diabetes. Metabolism. 2021; 125:154910. PMC: 8941799. DOI: 10.1016/j.metabol.2021.154910. View

5.
Seferovic P, Petrie M, Filippatos G, Anker S, Rosano G, Bauersachs J . Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018; 20(5):853-872. DOI: 10.1002/ejhf.1170. View